| 顾晔,孔亚荣,刘益宁,周慧,赵岩.孕中期胎儿大脑中动脉、孕妇子宫动脉血流参数联合血清miR-424对FGR胎儿预后的评估价值.[J].中南医学科学杂志.,2024,(1):110-112, 127. |
| 孕中期胎儿大脑中动脉、孕妇子宫动脉血流参数联合血清miR-424对FGR胎儿预后的评估价值 |
| Evaluation value of fetal middle cerebral artery and uterine artery blood flow combined with serum miR-424 in prognosis of fetal FGR during the second trimester |
| 投稿时间：2023-03-10 修订日期：2023-12-24 |
| DOI：10.15972/j.cnki.43-1509/r.2024.01.026 |
| 中文关键词: FGR 大脑中动脉血流 子宫动脉血流 miR-424 预后 [ |
| 英文关键词:FGR middle cerebral artery blood flow uterine arterial blood flow miR-424 prognosis |
| 基金项目:保定市科技计划项目(2241ZF040) |
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| 中文摘要: |
| 目的探究孕中期胎儿大脑中动脉(MCA)、孕妇子宫动脉(UtA)血流参数联合血清miR-424对生长受限(FGR)胎儿预后的评估价值。 方法选取FGR孕妇87例为观察组,同期产检健康的孕妇124例为对照组。FGR孕妇按照预后分为预后不良组和预后良好组。比较各组胎儿MCA、孕妇UtA血流和血清miR-424情况。采用ROC评估胎儿MCA、孕妇UtA血流和血清miR-424对FGR胎儿预后的评估价值。 结果孕妇血清miR-424观察组高于对照组,预后不良组高于预后良好组(P＜0.05)。胎儿MCA搏动指数(PI)及血流阻力指数(RI)观察组低于对照组,预后不良组低于预后良好组(P＜0.05)。孕妇UtA PI及RI观察组高于对照组,预后不良组高于预后良好组(P＜0.05)。胎儿MCA、孕妇UtA血流和血清miR-424联合检测对FGR胎儿预后具有良好的预测价值(P＜0.05)。 结论胎儿MCA、孕妇UtA血流和血清miR-424联合检测对FGR胎儿预后的预测效果更优,具有更高临床应用价值。 |
| 英文摘要: |
| AimTo investigate the value of middle cerebral artery (MCA) and maternal uterine artery (UtA) blood flow combined with serum miR-424 in the prognosis of fetal growth restricted (FGR) fetuses in the second trimester. MethodsA total of 87 FGR pregnant women were selected as the observation group and 124 healthy pregnant women were selected as the control group.FGR pregnant women were divided into poor prognosis group and good prognosis group according to the prognosis. Fetal MCA, maternal UtA blood flow and serum miR-424 were compared among all groups. ROC was used to evaluate the prognostic value of fetal MCA, UtA blood flow and serum miR-424 in FGR. ResultsSerum miR-424 in the observation group was higher than that in the control group, and the poor prognosis group was higher than that in the good prognosis group (P＜0.05). Fetal MCA pulse index (PI) and blood flow resistance index (RI) in observation group were lower than those in control group, and those in poor prognosis group were lower than those in good prognosis group (P＜0.05). The UtA PI and RI in the observation group were higher than those in the control group, and the poor prognosis group was higher than that in the good prognosis group (P＜0.05). The combined detection of fetal MCA, maternal UtA blood flow and serum miR-424 had a good predictive value for prognosis of fetal FGR (P＜0.05). ConclusionThe combined detection of fetal MCA, maternal UtA blood flow and serum miR-424 has better predictive effect on prognosis of fetal FGR, and has higher clinical application value compared with single detection. |
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