| 黄雅娉.阿托西班对新鲜胚胎种植率及妊娠结局的影响.[J].中南医学科学杂志.,2022,(3):429-431, 445. |
| 阿托西班对新鲜胚胎种植率及妊娠结局的影响 |
| Effect of Atosiban on fresh embryo implantation rate and pregnancy outcomes |
| 投稿时间：2021-09-13 修订日期：2021-11-03 |
| DOI：10.15972/j.cnki.43-1509/r.2022.03.030 |
| 中文关键词: 阿托西班 体外受精-胚胎移植 高龄 胚胎种植率 妊娠结局 |
| 英文关键词:atosiban in vitro fertilization-embryo transfer advanced age embryo implantation rate pregnancy outcomes |
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| 中文摘要: |
| 目的分析阿托西班对新鲜胚胎移植患者胚胎种植率及妊娠结局的影响。方法选择行新鲜胚胎移植术的患者60例,根据胚胎移植当日是否使用阿托西班分为观察组和对照组各30例。观察组胚胎移植术前30 min阿托西班静脉推注干预,对照组未使用阿托西班。对两组患者进行跟踪随访,记录两组胚胎种植率和妊娠结局；比较两组患者末次随访时的心理状态及治疗满意度；根据患者年龄,将观察组和对照组患者分为高龄组(年龄≥35岁)和常规组(年龄＜35岁),比较各组的胚胎种植率、临床妊娠率及活产率。结果观察组的胚胎种植率高于对照组(P＜0.05),两组临床妊娠率、异位妊娠、流产率、活产率比较差异无统计学意义(P＞0.05)；观察组末次随访时的抑郁评分低于对照组,满意度评分高于对照组(P＜0.05),而两组间的焦虑、恐怖评分差异无统计学意义(P＞0.05)；对照高龄组与对照常规组间的临床妊娠、活产率差异有统计学意义(P＜0.05),观察高龄组与对照高龄组间的临床妊娠、胚胎种植率和活产率比较差异有统计学意义(P＜0.05)。结论给予行新鲜胚胎移植术患者术前小剂量阿托西班预处理,可明显改善胚胎种植率和高龄患者妊娠结局。 |
| 英文摘要: |
| To analyze the effect of Atosiban on the embryo implantation rate and pregnancy outcomes of patients with fresh embryo transfer. Methods60 patients who underwent fresh embryo transfer were selected as the research subjects. According to whether Atosiban was used on the day of embryo transfer or not, the patients were divided into observation group and control group with 30 cases in each group. The observation group was given intravenous injection of Atosiban at 30 min before embryo transfer, and the control group was not given Atosiban. The two groups of patients were followed up, and the embryo implantation rate and pregnancy outcomes were recorded in the two groups. The psychological status and treatment satisfaction of the two groups of patients were compared at the last follow-up. The observation group and the control group were subdivided into advanced age subgroup (age ≥35 years old) and conventional subgroup (age＜35 years old) according to the age of patients. The embryo implantation rate, clinical pregnancy rates and live birth rate were compared between the subgroups. ResultsThe embryo implantation rate of observation group was significantly higher than that of control group (P＜0.05). There were no statistical differences in the clinical pregnancy rate, ectopic pregnancy, abortion rate and live birth rate between the two groups (P＞0.05). The depression score of observation group at the last follow-up was significantly lower than that of control group while the satisfaction score was significantly higher than that of control group (P＜0.05), but there were no statistically significant differences in the scores of anxiety and terror between the two groups (P＞0.05). Comparison of embryo implantation rate, clinical pregnancy rate and live birth rate among different subgroups showed that there was a statistically significant difference in live birth rate between advanced age subgroup and conventional subgroup of control group (P＜0.05), and there was a statistical significance in the clinical pregnancy, embryo implantation rate and live birth rate between advanced subgroups of observation group and control group (P＜0.05). ConclusionPreoperative treatment with a small dose of Atosiban for patients undergoing fresh embryo transfer can significantly improve the embryo implantation rate, and pregnancy outcomes in elderly patients. |
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