| 张岱阳,李拓,罗政,尹锐,胡睿.EZH2在强直性脊柱炎患者中的表达及与Th17分化的关系.[J].中南医学科学杂志.,2020,(1):84-87. |
| EZH2在强直性脊柱炎患者中的表达及与Th17分化的关系 |
| Expression of EZH2 in patients with ankylosing spondylitis and its relationship with Th17 differentiation |
| 投稿时间：2019-09-30 修订日期：2019-12-20 |
| DOI：10.15972/j.cnki.43-1509/r.2020.01.022 |
| 中文关键词: Zesle基因增强子2 强直性脊柱炎 表达水平 Th17 相关性 细胞 |
| 英文关键词:EZH2 ankylosing spondylitis expression level Th17 correlation cell |
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| 中文摘要: |
| 观察果蝇Zesle基因增强子2(EZH2)在强直性脊柱炎患者中的表达及与辅助性T细胞17(Th17)分化的关系。选择本院收治的强直性脊柱炎患者84例为病例组,同期健康体检者50例为对照组,检测外周血单个核细胞中EZH2与Th17细胞比率、IL-6、IL-17、IL-23、TGF-β的水平和相关性。结果显示,与对照组相比,病例组外周血单个核细胞中EZH2与Th17细胞比率、IL-6、IL-17、IL-23、TGF-β的水平均显著升高；EZH2在患者外周血中呈高表达且与Th17分化呈正相关。结果说明,EZH2可能通过刺激Th17细胞分化,促进自身抗体形成,参与强直性脊柱炎发生发展。 |
| 英文摘要: |
| To explore the expression of Drosophila Zesle gene enhancer 2 (EZH2) in patients with ankylosing spondylitis and its relationship with helper T cell 17 (Th17) differentiation. 84 patients with ankylosing spondylitis admitted to our hospital were selected as the case group. 50 healthy controls were used as the control group,the levels and correlations EZH2 between IL-17, IL-23, and TGF-β were analyzed. Results showed compared to the control group, the ratio of EZH2 and Th17, and the levels of IL-6, IL-17, IL-23 and TGF-β in peripheral blood in the case group were significant higher, and EZH2 is positively correlated with Th17 differentiation. Results indicated that EZH2 may promote the formation of autoantibodies by stimulating the differentiation of Th17 cells and participate in the development of ankylosing spondylitis. |
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