张红,宋艳芳,安鑫.高通量血液透析对尿毒症患者肾功能的研究.[J].中南医学科学杂志.,2019,(6):637-639.
高通量血液透析对尿毒症患者肾功能的研究
Study on renal function in uremic patients by high flux hemodialysis
投稿时间:2018-11-16  修订日期:2019-05-17
DOI:10.15972/j.cnki.43-1509/r.2019.06.019
中文关键词:  血液透析  高通量透析  低通量透析  终末期肾病  肾性骨病
英文关键词:hemodialysis  high flux dialysis  low flux dialysis  end stage renal disease  renal osteodystrophy
基金项目:
作者单位
张红 新疆克拉玛依市中心医院肾病风湿病科,新疆 克拉玛依834000 
宋艳芳 新疆克拉玛依市中心医院肾病风湿病科,新疆 克拉玛依834000 
安鑫 新疆克拉玛依市中心医院肾病风湿病科,新疆 克拉玛依834000 
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中文摘要:
      为研究高通量血液透析对终末期肾病(ESRD)患者肾性骨病相关毒素分子水平影响,选择血液透析治疗的ESRD患者,分为高通量透析组和低通量透析组,进行透析治疗,分别于透析前和透析6个月后测定血尿素氮(BUN)、血清肌酐(Cr)、血钙(Ca)、血磷(P)、IL-8、TNF-α、血红蛋白等。结果显示,透析后,与低通量组相比,高通量组患者的BUN、Cr、Ca及P的水平明显降低,且PTH水平也明显降低。所以,高通量血液透析比低通量血液透析更能够明显降低ESRD患者肾性骨病相关毒素分子水平。
英文摘要:
      To study the effect of high throughput hemodialysis on the molecular level of toxin related to renal bone disease in patients with end-stage renal disease (ESRD), patients with ESRD treated by hemodialysis were divided into high-flux dialysis group and low-flux dialysis group. Blood urea nitrogen (BUN), creatinine (Cr), calcium (Ca), phosphorus (P), IL-8, TNF-alpha (TNF-α ) and hemoglobin were measured before and 6 months after dialysis. Results show, compared to the low flux group after dialysis, the levels of BUN, Cr, Ca and P in the high flux group after dialysis were significantly lower, PTH level was significantly lower. So, high-flux hemodialysis significantly can reduce the molecular level of renal osteopathy-related toxins in ESRD patients than that of low-flux hemodialysis.
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