刘红娟.左西孟旦联合rh-BNP对脓毒症致急性心力衰竭患者心功能及细胞凋亡蛋白的影响分析.[J].中南医学科学杂志.,2019,(6):606-609.
左西孟旦联合rh-BNP对脓毒症致急性心力衰竭患者心功能及细胞凋亡蛋白的影响分析
Effect of levosimendan combined with rh-BNP on cardiac function and apoptotic protein in patients with sepsis-induced acute heart failure
投稿时间:2019-04-29  修订日期:2019-08-25
DOI:10.15972/j.cnki.43-1509/r.2019.06.011
中文关键词:  左西孟旦  重组人脑利钠肽  脓毒症  急性心力衰竭  心功能  细胞凋亡蛋白
英文关键词:levosimendan  recombinant human brain natriuretic peptide  sepsis  acute heart failure  cardiac function  apoptotic protein
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作者单位
刘红娟 河北省石家庄市第一医院重症医学科,河北 石家庄050000 
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中文摘要:
      分析左西孟旦联合重组人脑利钠肽(rh-BNP)治疗脓毒症致急性心力衰竭患者疗效及作用机制。130例脓毒症致急性心力衰竭患者均接受抗感染、强心、利尿等基础治疗措施。对照组(n=65)患者在基础治疗的基础上给予左西孟坦联合多巴酚丁胺治疗,观察组(n=65)患者在基础治疗的基础上给予左西孟坦联合rh-BNP治疗。结果显示两组患者经治疗后左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)均显著降低而射血分数(LVEF)均显著升高(P<0.05),Bax及Caspase3均显著降低而Bcl2明显升高(P<0.05),心肌酶谱LDH、CK-MB及CK均显著降低(P<0.05)。与对照组患者相比,观察组患者的上述指标变化更显著(P<0.05)。两组患者的总不良反应发生率比较,差异无显著性(P>0.05)。 左西孟旦联合rh-BNP对脓毒症致急性心力衰竭患者心功能及心肌酶谱有显著的改善作用,且能明显调控异常的细胞凋亡蛋白表达。
英文摘要:
      To investigate the effects of levosimendan combined with recombinant human brain natriuretic peptide (rh-BNP) on cardiac function and its effects on apoptotic protein levels in patients with sepsis-induced acute heart failure. 130 patients with acute heart failure received basic treatment measures including anti-infection, cardiotonic therapy and diuresis. The control group patients (n=65) were treated with levosimontan combined with dobutamine on the basis of basic treatment. The observation group patients (n=65) were treated with levosimontan combined with rh-BNP on the basis of basic treatment. The results showed that the levels of LVEDD and LVESD were significantly decreased and the levels of LVEF were significantly increased in both groups (P<0.05) after treatment. The expression of Bax and Caspase 3 were decreased significantly while Bcl2 increased significantly (P<0.05) after treatment. LDH, CK-MB and CK of myocardium were significantly decreased (P<0.05) after treatment. Compared with the control group, these changes of the above indexes in the observation group were more significant (P<0.05). There was no statistical difference in the incidence of total adverse reactions between the two groups (P>0.05). Levosimendan combined with rh-BNP can significantly improve cardiac function and myocardial enzymes in patients with sepsis-induced acute heart failure, and can significantly regulate abnormal apoptotic protein expression.
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