| 符晶,孟开顺.法舒地尔对ICH大鼠炎性因子水平、神经及认知功能的影响.[J].中南医学科学杂志.,2019,(5):488-491. |
| 法舒地尔对ICH大鼠炎性因子水平、神经及认知功能的影响 |
| Effect of fasudil on inflammatory response, neurological and cognitive function recovery in ICH rats |
| 投稿时间：2018-11-21 修订日期：2019-07-08 |
| DOI：10.15972/j.cnki.43-1509/r.2019.05.011 |
| 中文关键词: 盐酸法舒地尔 脑出血 炎性反应 神经功能 认知功能 |
| 英文关键词:Fasudil hydrochloride cerebral hemorrhage inflammatory response neurological function cognitive function |
| 基金项目: |
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| 中文摘要: |
| 为探讨盐酸法舒地尔治疗脑出血(ICH)大鼠对炎性因子水平、神经功能及认知功能恢复的影响。选取健康成年Wistar雄性大鼠随机分为对照组、模型组和治疗组,模型组和治疗组采用非抗凝自体股动脉血注入右侧尾状核建立ICH大鼠模型,治疗组采取腹腔注射盐酸法舒地尔每天12 mg/kg,模型组和对照组均给予等量的生理盐水；对比各组大鼠的Morris水迷宫试验逃避潜伏期、穿越平台次数、神经功能缺损评分、IL-6、TNF-α、NF-κB。结果显示,盐酸法舒地尔治疗ICH大鼠能显著的改善大鼠神经及认知功能、降低脑出血后大鼠的炎症反应程度。 |
| 英文摘要: |
| To investigate the effects of fasudil hydrochloride on the recovery of inflammatory factors, neurological function and cognitive function in rats with cerebral hemorrhage (ICH). Healthy adult Wistar male rats were randomly divided into model group, treatment group and control group. Model group and treatment group were injected with non-anticoagulated autologous femoral artery blood into the right caudate nucleus to establish ICH rat model. The treatment group received intraperitoneal injection of hydrochloric acid, Fasudil 12mg/kg per day, the model group and the control group were given the same amount of normal saline; it compared with the escape latency of the Morris water maze test, the number of crossing platforms, the neurological deficit score, IL-6, TNF-α, NF-κB of each group. The results showed that fasudil hydrochloride treatment of ICH rats can significantly improve the neurological and cognitive functions of rats, and reduce the degree of inflammatory response in rats after cerebral hemorrhage. |
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