| 李修晶,石静云,赵芳萍.神经节苷酯治疗新生儿缺氧缺血性脑病对患儿神经相关因子及脑神经损伤程度影响分析.[J].中南医学科学杂志.,2019,(4):389-392. |
| 神经节苷酯治疗新生儿缺氧缺血性脑病对患儿神经相关因子及脑神经损伤程度影响分析 |
| Effect of Ganglioside on Neuro-related Factors and Degree of Cerebral Nerve Injury in Neonates with Hypoxic-ischemic Encephalopathy |
| 投稿时间：2018-12-25 修订日期：2019-05-16 |
| DOI：10.15972/j.cnki.43-1509/r.2019.04.013 |
| 中文关键词: 神经节苷酯 新生儿缺氧缺血性脑病 神经相关因子 脑血流动力学 |
| 英文关键词:ganglioside neonatal hypoxic-ischemic encephalopathy neuro-related factors cerebral hemodynamics |
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| 中文摘要: |
| 分析神经节苷酯治疗新生儿缺氧缺血性脑病(HIE)对患儿神经相关因子及脑神经损伤程度的影响。选取本院收治的HIE患儿96例,分为两组。对照组患儿采用常规治疗,观察组患儿采用常规治疗联合神经节苷酯治疗,分析两组患儿治疗后的临床疗效。观察组肌张力、原始反射及意识恢复恢复时间短于对照组(P<0.05)。治疗后,观察组NGF水平高于对照组,NSE、Caspase3、MBP水平低于对照组,收缩期峰值流速和舒张末期流速快于对照组,但阻力指数与对照组比较。治疗7、28天后,观察组患儿NBNA评分高于对照组。结果说明,神经节苷酯治疗HIE可促进患儿临床症状的恢复,改善神经相关因子表达水平和脑血流动力学参数,减轻脑神经损伤程度。 |
| 英文摘要: |
| To analyze the effect of ganglioside on the nerve-related factors and the degree of brain nerve injury in neonates with hypoxic-ischemic encephalopathy (HIE). 96 cases of HIE in our hospital were divided into two groups. The children in the control group were treated with routine therapy and the patients in the observation group were treated with ganglioside. The clinical effects of the two groups were analyzed. The time of muscle tension, primordial reflex and consciousness recovery in the observation group were shorter than that in the control group (P<0.05). After treatment, the level of NGF in the observation group was higher than that in the control group, and the levels of NSE,Caspase3,MBP in the observation group were lower than that in the control group. The peak systolic velocity and the end diastolic velocity were faster than those in the control group, but there was no significant difference in resistance index between the two groups. On the 7th and 28th day after treatment, the NBNA score in the observation group was higher than that in the control group (P<0 05). The treatment of HIE with ganglioside can promote the recovery of clinical symptoms, improve the expression level of nerve-related factors and cerebral hemodynamic parameters, and reduce the degree of brain nerve injury. |
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