| 胡绘平,李正涛,厉兰,周博,刘文春.注射用阿糖腺苷结合干扰素雾化吸入治疗小儿疱疹性咽峡炎的临床研究.[J].中南医学科学杂志.,2019,(3):288-290. |
| 注射用阿糖腺苷结合干扰素雾化吸入治疗小儿疱疹性咽峡炎的临床研究 |
| Efficacy of vidarabine for injection combined with interferon inhalation in the treatment of herpetic angina in children |
| 投稿时间：2018-11-10 修订日期：2019-02-12 |
| DOI：10.15972/j.cnki.43-1509/r.2019.03.016 |
| 中文关键词: 阿糖腺苷 干扰素 雾化吸入 小儿疱疹性咽峡炎 疗效 |
| 英文关键词:adenosine arabinoside interferon inhalation herpetic angina in children curative effect |
| 基金项目: |
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| 中文摘要: |
| 由于近年来小儿疱疹性咽峡炎越发常见,患儿感染后常夜间哭闹不止,对其家人生活造成严重干扰,且目前临床上治疗小儿疱疹性咽峡炎效果不佳,无法治愈。本研究选取小儿疱疹性咽峡炎124例,分别采用单独阿糖腺苷注射疗法、阿糖腺苷注射与干扰素雾化吸入联合治疗。结果发现阿糖腺苷注射与干扰素雾化吸入联合治疗患儿的临床总有效率、患儿的退热时间、咽痛消失时间、溃疡愈合时间、疱疹消失时间均优于单独阿糖腺苷注射疗法；此外,阿糖腺苷注射与干扰素雾化吸入联合治疗CD4+、CD4+/CD8+、IL-10均高于单独阿糖腺苷注射疗法,且CD8+和IFN-γ低于单独阿糖腺苷注射疗法。综上所述,阿糖腺苷注射结合干扰素雾化吸入治疗小儿疱疹性咽峡炎,能够显著提高疗效,明显改善患儿症状,值得临床推广应用。 |
| 英文摘要: |
| In recent years, children with herpetic angina have become more and more common. Children often cry at night after infection, which causes serious problems to their families. At present, clinical treatment of children with herpetic angina is not effective and can not be cured. In this study, 124 children with herpetic angina were treated with adenosine-arabinoside injection alone, adenosine-arabinoside injection combined with interferon aerosol inhalation. The results showed that the clinical total effective rate, fever abatement time, pharyngalgia disappearance time, ulcer healing time and herpes disappearance time of children treated with adenosine-arabinoside injection combined with interferon aerosol inhalation were better than those treated with adenosine-arabinoside injection alone; in addition, adenosine-arabinoside injection combined with interferon aerosol inhalation in the treatment of CD4+, CD4 8+, IL-10 was better that of single adenosine-arabinose injection therapy, and CD8+ and IFN-gamma were lower than that of single adenosine-arabinose injection therapy. To sum up, adenosine arabinose injection combined with interferon aerosol inhalation can significantly improve the efficacy and symptoms of children with herpes angina, which is worthy of clinical application. |
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