| 尹文君,王秋平,刘双全,姜孝新.MiR-193b在肝癌组织中的表达及临床意义.[J].中南医学科学杂志.,2018,(6):621-624. |
| MiR-193b在肝癌组织中的表达及临床意义 |
| Expression of miR-193b in hepatic cancer tissue and its clinical significance |
| 投稿时间：2018-03-09 修订日期：2018-08-14 |
| DOI：10.15972/j.cnki.43-1509/r.2018.06.016 |
| 中文关键词: miR-193b 肝癌 qRT-PCR 病理特征 生存率 |
| 英文关键词:miR-193b hepatic cancer qRT-PCR pathological features survival rate |
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| 中文摘要: |
| 观察microRNA-193b(miR-193b)在肝癌组织中的表达,并探讨其临床意义。采用荧光实时定量PCR(qRT-PCR)检测40例肝癌组织及相应的癌旁非肿瘤组织标本中miR-193b表达,分析miR-193b表达与患者年龄、性别、肿瘤大小、分化程度、TNM分期及淋巴结转移等临床病理参数的关系,并比较miR-193b高、低表达患者5年生存率。结果显示,相对于癌旁非肿瘤组织,肝癌组织中miR-193b 表达水平明显降低(P<0.01),miR-193b表达与肿瘤分化程度、TNM分期和淋巴结转移相关(P<0.05),与年龄、性别、肿瘤大小无相关性(P>0.05)；与miR-193b低表达组患者相比,高表达组患者5年生存率明显增加(P<0.05)。MiR-193b在肝癌组织呈低表达,可作为评估肿瘤恶性程度及判断预后的分子标记物。 |
| 英文摘要: |
| To observe the expression of microRNA-193b (miR-193b) in hepatic cancer tissue and explore its clinical significance. Quantitative real-time PCR (qRT-PCR) was used to detect the expression of miR-193b in 40 hepatic cancer and corresponding paracancerous tissue samples. Relationship between miR-193b expression and patients' age, sex, tumor size, differentiation degree, TNM period, and lymph node metastasis was analyzed. In addition, five-year survival rate was compared between cases with high miR-193b expression and ones with low miR-193b expression. In comparison with paracancerous tissue, miR-193b expression levels were significantly decreased in hepatic cancer tissue (P<0.01). The expression of miR-193b was associated with differentiation degree, TNM period and lymph node metastasis (P<0.05), but not age, sex and tumor size (P>0.05). Five-year survival rate was higher in high miR-193b expression group than low miR-193b expression group (P<0.05). These findings suggest that miR-193b is lowly expressed in hepatic cancer tissue and may serve as a molecular marker for evaluating the degree of tumor malignance and judging the prognosis. |
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