冯家豪,吴岳,罗永百,范晓娟,宁小康,陈学彬,武向阳,折剑青.阿司匹林分别与替格瑞洛或氯吡格雷联合对PCI术后抗凝疗效的观察.[J].中南医学科学杂志.,2018,(6):580-582, 585.
阿司匹林分别与替格瑞洛或氯吡格雷联合对PCI术后抗凝疗效的观察
Eurative effects of tigrolil and aspirin on prevention of cardiovascular accident and PCI
投稿时间:2018-06-10  修订日期:2018-07-11
DOI:10.15972/j.cnki.43-1509/r.2018.06.005
中文关键词:  急性心肌梗死  经皮冠状动脉介入支架术  替格瑞洛  阿司匹林  氯吡格雷
英文关键词:acute myocardial infarction  percutaneous coronary intervention  ticagrelor  aspirin  clopidogrel
基金项目:
作者单位
冯家豪 西安交通大学第一附属医院心内科,710061 
吴岳 西安交通大学第一附属医院心内科,710061 
罗永百 西安交通大学第一附属医院心内科,710061 
范晓娟 西安交通大学第一附属医院心内科,710061 
宁小康 陕西中医药大学附属医院心内科 
陈学彬 陕西中医药大学附属医院心内科 
武向阳 陕西中医药大学附属医院心内科 
折剑青 西安交通大学第一附属医院心内科,710061 
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中文摘要:
      观察阿司匹林分别与替格瑞洛或氯吡格雷联合对经皮冠状动脉介入术(PCI) 后抗凝疗效和防治心血管意外效果,初步探讨这两种药物联合在PCI术后的治疗价值。结果显示,两组联合用药后患者左室射血分数(LVEF)、每搏心输出量(SV)、中心静脉压(CVP)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板(PLT)、血小板抑制率明显高于治疗前。阿司匹林联合替格瑞洛对 LVEF、SV、CVP、PT、APTT、PLT、血小板抑制率明显高于联合氯吡格雷,在预防左室舒张末内径(LVEDD)、出血率、心脏不良事件发生率与阿司匹林联合氯吡格雷差异不显著。结果提示,阿司匹林与替格瑞洛联合治疗不仅能够有效改善患者的凝血功能和血小板抑制能力,而且临床不良事件少、出血风险小,是PCI术后安全、有效的抗凝治疗方案之一。
英文摘要:
      To observe the anticoagulant effect of combination of aspirin and teicrin or clopidogrel?on the prevention of cardiovascular accident after percutaneous coronary intervention (PCI), and evaluation of their therapeutic value. Results show treatment with combination of the sorts of combination drugs, the LVEF, SV, CVP, PT, APTT, PLT, platelet inhibition rate was significantly higher than before treatment. Compare to unite with clopidogrel, the LVEF, SV, CVP, PT, APTT, PLT, platelet inhibition was significantly higher in combination of teicrin, prevention of the LVEDD, rate of bleeding adverse cardiac events and the incidence was similar between two combiantion group. Therapy aspirin with ticagrelor can not only effectively double anti-coagulation and improve the patient's ability to inhibit platelet, and less adverse clinical events, a small risk of bleeding after PCI, this combination therapeutic regimen is a safe and effective for anticoagulation treatment.
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