| 俞巍.胸腔镜手术治疗老年早期肺癌的效果及对术后氧化应激的影响分析.[J].中南医学科学杂志.,2018,(5):535-537. |
| 胸腔镜手术治疗老年早期肺癌的效果及对术后氧化应激的影响分析 |
| Effect of thoracoscopic surgery in the treatment of early lung cancer in the elderly and its effect on postoperative oxidative stress |
| 投稿时间：2018-05-02 修订日期：2018-09-01 |
| DOI：10.15972/j.cnki.43-1509/r.2018.05.024 |
| 中文关键词: 胸腔镜 开胸手术 早期肺癌 氧化应激 炎症因子 |
| 英文关键词:thoracoscopy thoracotomy early lung cancer oxidative stress inflammatory factors |
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| 中文摘要: |
| 本文分析胸腔镜手术治疗老年早期肺癌的效果及对氧化应激的影响,为临床治疗提供参考。回顾性分析本院2014年6月至2017年6月期间早期肺癌接受肺叶切除术患者临床资料,其中胸腔镜手术切除组80例(胸腔镜组),传统开胸肺叶切除术患者60例(传统开胸组),分析两组患者的手术效果及术后氧化应激相关分子的水平变化。结果与传统开胸组相比,胸腔镜组患者手术时间和胸腔引流管时间及住院时间明显缩短,术后30天视觉模拟评分法(VAS)评分明显降低(P<0.05)；传统开胸组和胸腔镜组患者治疗后还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶2(NOX2)、NOX4、白细胞介素2(IL2)及白细胞介素6(IL6)水平均明显降低,且胸腔镜组患者下降更显著(P<0.05)。因此,胸腔镜手术治疗对老年早期肺癌有较好的治疗效果,且能够有效降低氧化应激及炎症反应相关蛋白水平。 |
| 英文摘要: |
| The effect of thoracoscopic surgery in the treatment of early lung cancer in the elderly and the effect on oxidative stress were analyzed in this study.Clinical data of patients undergoing pulmonary lobectomy of our hospital from June 2014 to June 2017 during the early stage of lung cancer were retrospectively analyzed.In this study, 80 cases treated with VATS resection (VATS group) and 60 cases treated with conventional thoracotomy lobectomy(traditional thoracotomy group) were assayed.The effect of the two groups of patients and the changes in the levels of oxidative stress related molecules after operation were analyzed. Compared with the traditional thoracotomy group, the operative time and the time of drainage and the length of stay in the thoracoscopic group were significantly shorter, and the 30dVAS score was significantly lower after operation (P<0.05).The levels of NOX2, NOX4, IL2 and IL6 in the traditional thoracotomy group and the thoracoscopy group were significantly decreased, and the patients in the thoracoscopy group decreased more significantly (P<0.05).So thoracoscopic surgery has a good therapeutic effect on early lung cancer in the elderly, and can effectively reduce the level of oxidative stress and inflammatory response related proteins. |
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