| 朱 斌，薛玉珍，惠 薇.腹腔镜治疗子宫内膜异位症性不孕对.[J].中南医学科学杂志.,2015,43(4):408-410. |
| 腹腔镜治疗子宫内膜异位症性不孕对 |
| Effect of Galectin-3 in the Endometrium on Endometriosis-associated Infertility After Laparoscopic Surgery |
| 投稿时间：2015-04-18 |
| DOI： |
| 中文关键词: 子宫内膜异位症 不孕症 腹腔镜 子宫内膜容受性Galectin-3蛋白 |
| 英文关键词:endometriosis infertility laparoscopy endometrial receptivity galectin-3 |
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| 中文摘要: |
| 目的 通过检测腹腔镜治疗子宫内膜异位症性不孕症术后子宫内膜Galectin-3蛋白表达变化，探讨手术治疗与子宫内膜容受性的关系。 方法 采用免疫组化法，检测子宫内膜异位症性不孕症腹腔镜治疗术后Galectin-3蛋白表达。按照研究对象入组标准，选择男方因素不孕症组52例，子宫内膜异位症性不孕症组54例，其中子宫内膜异位症Ⅰ～Ⅱ期组28例，子宫内膜异位症Ⅲ～Ⅳ期组26例。 结果 子宫内膜异位症性不孕症组Galectin-3蛋白表达低于男方不孕症组（P<0.05）；腹腔镜手术治疗子宫内膜异位症不孕症术后，与术前比较Galectin-3蛋白表达升高（P<0.05）；子宫内膜异位症Ⅰ～Ⅱ期组与Ⅲ～Ⅳ期组分别于术前、术后比较，Galectin-3蛋白表达差异无显著性（P>0.05）。 结论 子宫内膜异位症性不孕症患者存在子宫内膜容受性下降，腹腔镜手术可通过上调Galectin-3蛋白表达改善子宫内膜容受性。 |
| 英文摘要: |
| Objective To investigate the expression of galectin-3 in infertile women with endometriosis after laparoscopic surgery. Methods Immunohistochemistry was used to detect the expression of galectin-3 proteinin in endometriosis-associated infertility after laparoscopic surgery.According to the research subjects，52 cases of healthy women with male factor infertility and 54 cases with endometriosis（stageⅠ～Ⅱ 28 cases and stageⅢ～Ⅳ 26 cases） were analyzed. Results The expression of galectin-3 in endometriosis-associated infertility was significantly lower than those of healthy women with male factor infertility（P<0.05），while after laparoscopic surgery the expression was significantly higher than those before surgery（P<0.05）.The expression of galectin-3 was not significantly different between different stages of endometriosis-associated infertility （P>0.05）. Conclusion Endometriosis may decrease endometrial receptivity.The up-regulated expression of galectin-3 in the endometrium may be the reasons which lead to the improvement of endometrial receptivity in endometriosis-associated infertility after laparoscopic surgery. |
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