| 欧琼，黄余良，张群锋.槟榔碱对去卵巢骨质疏松大鼠骨代谢的影响.[J].中南医学科学杂志.,2015,43(1):31-34. |
| 槟榔碱对去卵巢骨质疏松大鼠骨代谢的影响 |
| Effect of Arecoline on the Bone Metabolism in Ovariectomized Rats with Osteoporosis |
| 投稿时间：2014-09-04 |
| DOI： |
| 中文关键词: 槟榔碱 去卵巢 骨质疏松 骨密度 |
| 英文关键词:arecoline ovariectomized osteoporosis boneminaral density |
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| 中文摘要: |
| 目的探讨槟榔碱对去卵巢骨质疏松（OP）大鼠骨代谢的影响。方法50只健康SD雌性大鼠随机分为对照组、模型组、低、中和高剂量槟榔碱组（1、5、20mg/kg，每天灌胃1次）。12周后检测尿钙和尿脱氧吡啶啉（Dpd）及血清钙、血清磷、血碱性磷酸酶（ALP）和雌二醇（E2）水平。采用双能X射线吸收法测量大鼠右侧股骨的骨密度（BMD）。取股骨进行3点弯曲生物力学试验。结果与对照组比较，模型组大鼠血清E2水平和BMD显著降低（P<0.05），尿钙、尿Dpd、血清钙、血清磷和ALP水平均显著增加（均P<0.05），左侧股骨的生物力学指标包括最大载荷、最大挠度、弹性载荷和弯曲能量均显著降低（均P<0.05）。与模型组比较，中和高剂量槟榔碱组大鼠股骨的BMD显著增加（P<0.05），尿钙、尿Dpd、血清钙、血清磷和ALP水平显著降低（均P<0.05），左侧股骨的最大载荷、最大挠度、弹性载荷和弯曲能量均显著增加（均P<0.05）。结论槟榔碱改善了去卵巢OP大鼠的骨代谢，增强其骨密度，改善骨生物力学指标。 |
| 英文摘要: |
| Objective To investigate the effect of arecoline on the bone metabolism in ovariectomized rats with osteoporosis. Methods The fifty SD female rats were randomly divided into sham control,ovariectomized osteoporosis model,and low,middle and high dose arecoline group.Arecoline （1,5 and 20 20 mg/kg） was administered by lavage every day.After 12 weeks,the levels of urine calcium and deoxypyridinoline （Dpd）,serum calcium,serum phosphorus,serum alkaline phosphatase （ALP） and estradiol （E2） were measured.Bone mineral density （BMD） was measured by a dual-energy X-ray absorptiometry.3 point bend testing of femur was accomplished. Results Compared with the sham control group,the levels of E2 and BMD were significantly decreased （all P<0.05）,the levels of urine calcium and Dpd,serum calcium,serum phosphorus and serum ALP were significantly increased （all P<0.05） and the biomechanical indexes including maximum load,maximum deflection,elastic load and bending energy were significantly decreased （all P<0.05） in the ovariectomized osteoporosis model group.Compared with the ovariectomized osteoporosis model group,the level of BMD were significantly increased,the levels of urine calcium and Dpd,serum calcium,serum phosphorus and serum ALP were significantly decreased （all P<0.05） and the maximum load,maximum deflection,elastic load and bending energy were significantly increased （all P<0.05） in the ovariectomized osteoporosis model group. Conclusion Arecoline improves the bone metabolism,increases BMD and improves the biomechanical indexes of bone. |
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