| 龚邵新，赵强，曾庆彪，丁慧.ER、PR和C-erbB-2在乳腺浸润性导管癌中的表达及其相关性.[J].中南医学科学杂志.,2011,39(3):314-316. |
| ER、PR和C-erbB-2在乳腺浸润性导管癌中的表达及其相关性 |
| Expression and Clinical Significance of ER、PR and C-erbB-2 in Breast Infiltrating Ductal Carcinoma |
| 投稿时间：2010-12-31 |
| DOI： |
| 中文关键词: 乳腺癌 ER PR C-erbB-2 免疫组化 |
| 英文关键词:breast cacer ER PR C-erbB-2 immunohistochemistry |
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| 中文摘要: |
| 目的探讨ER、PR和C-erbB-2在乳腺浸润性导管癌中的表达及其相关性。方法收集84例乳腺浸润性导管癌石蜡标本，应用免疫组化“二步法”检测ER、PR和C-erbB-2在上述病变中的表达。结果ER阳性57例，PR阳性42例，C-erbB-2阳性58例，ER、PR和C-erbB-2表达与乳腺癌患者年龄、肿瘤大小、淋巴结转移情况没有明显相关性。ER和PR的表达与C-erbB-2的表达没有明显相关性。ER、PR表达呈正相关。乳腺癌患者的年龄与淋巴结是否转移没有明显相关性。结论ER、PR和C-erbB-2的表达与临床各因素无明显相关性，联合检测ER、PR及C-erbB-2对临床上判断乳腺癌预后、指导治疗的意义不确定。 |
| 英文摘要: |
| ObjectiveTo study the expression and clinical significance of ER,PR and C-erbB-2 in breast infiltrating ductal carcinoma.MethodsThe samples of 84 breast infiltrating ductal carcinoma were collected,then the expression of ER,PR and C-erbB-2 were detected with 2 step method.ResultsThe positive expression of ER,PR and C-erbB-2 were 57,42,58 respectively,which weren’t correlated with patient age,lump size and lymphatic metastasis.The expression of ER and PR had no correlation with the expression of C-erbB-2(P>0.05).The expression of Er was positively correlated with the expression of PR(P<0.05).ConclusionsThere were no obvious relations between the expression of ER,PR,C-erbB-2 and clinical factors.The expression of ER,PR and C-erbB-2 has an indefinite significance for predicting the prognosis of breast cancer paients. |
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