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pH/近红外光双响应卡培他滨智能印迹材料的制备及药物释放研究 |
A smart capecitabine imprinted nanocontainer with the dual-responsive performance to pH/NIR light |
投稿时间:2024-01-13 修订日期:2024-03-13 |
DOI: |
中文关键词: 卡培他滨 pH/近红外光 刺激响应 智能印迹材料 上转换纳米粒子 |
英文关键词:Capecitabine pH/NIR light Stimulus-responsive Smart imprinted material Upconversion nanoparticle |
基金项目:湖南省自然科学基金面上项目(2020JJ4520);国家大学生创新训练项目(S202310555074) |
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中文摘要: |
以广谱抗癌药物卡培他滨CAP为模板,上转换纳米粒子为载体,3,5-二羧基-4-甲基丙烯酸酯偶氮苯和丙烯酸官能化明胶为双官能单体,N,N"-亚甲基双丙烯酰胺为交联剂,过硫酸铵为引发剂,采用表面聚合及分子印迹技术制备了具有pH值/近红外光双响应性能的纳米智能药物载体CAP-MIP。实验结果表明,CAP-MIP不仅具有较好的载药活性(吸附容量7.00 mg?g-1),而且还具有良好的吸附选择性(CAP选择性因子α 2.904)。当介质pH分别为1.2、6.8、8.3时,CAP的最大累积释放率分别为1.71%、41.84%、89.54%,药物释放的平衡时间分别为40 min、180 min及420 min。当介质pH为6.8,且伴有近红外光(λ=980 nm)照射时,目标材料仅180 min就能使CAP达到最大累积释放率96.21%。此外,CAP-MIP还具有良好的稳定性,经过7次吸附-解吸循环后,CAP-MIP载药量损失率仅为8.29%。上述信息充分表明,目标材料在药物递送系统中将具有十分广阔的应用前景。 |
英文摘要: |
By utilizing a broad-spectrum anticancer drug capecitabine CAP as the template, upconversion nanoparticle as the carrier, 3,5-dicarboxy-4-methylacrylic ester azobenzene and acrylated gelatin as the bifunctional monomers, N,N"-methylenebisacrylamide as the cross-linker, and ammonium persulfate as the initiator, a pH/near-infrared dual-responsive nano-intelligent drug carrier named CAP-MIP, was successfully synthesized. The synthesis process involved the surface polymerization and the molecular imprinting technique, and the experimental results revealed that CAP-MIP exhibited the outstanding drug-loading activity, with an adsorption capacity of 7.00 mg?g-1, and the remarkable adsorption selectivity (CAP selectivity factor α of 2.904). The maximum cumulative release rates of CAP at the media with pH values of 1.2, 6.8, and 8.3 were 1.71%, 41.84%, and 89.54%, respectively, with the related equilibrium release times of 40 min, 180 min, and 420 min. Under the condition of pH 6.8 and NIR irradiation (λ=980 nm), CAP-MIP demonstrated a rapid release, reaching a maximum cumulative release rate of 96.21% with just 180 min. Furthermore, the stability of CAP-MIP was evident, with a drug loss rate of only 8.29% after seven adsorption-desorption cycles. These findings emphasize the significant potential of the developed material for the application in drug delivery system. |
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