| 谭倪,曾忱思,龚岩芳,齐晨汐,曾湘华.pH/近红外光双响应卡培他滨智能印迹材料的制备及药物释放研究[J].南华大学学报(自然科学版),2024,(3):79~89.[TAN Ni,ZENG Chensi,GONG Yanfang,QI Chenxi,ZENG Xianghua.Preparation and Drug Release Study of Capecitabine Smart Imprinting Material with Dual-responsive Performance of pH/NIR Light[J].Journal of University of South China(Science and Technology),2024,(3):79~89.] |
| pH/近红外光双响应卡培他滨智能印迹材料的制备及药物释放研究 |
| Preparation and Drug Release Study of Capecitabine Smart Imprinting Material with Dual-responsive Performance of pH/NIR Light |
| 投稿时间：2024-01-13 |
| DOI： |
| 中文关键词: 卡培他滨 pH/近红外光 刺激响应 智能印迹材料 上转换纳米粒子 |
| 英文关键词:capecitabine pH/NIR light stimulus-responsive smart imprinting material upconversion nanoparticle |
| 基金项目:湖南省自然科学基金面上项目(2020JJ4520);国家大学生创新训练项目(S202310555074) |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 以广谱抗癌药物卡培他滨(capecitabine,CAP)为模板,上转换纳米粒子为载体,3,5-二羧基-4-甲基丙烯酸酯偶氮苯和丙烯酸官能化明胶为双官能单体,N,N′-亚甲基双丙烯酰胺为交联剂,过硫酸铵为引发剂,采用表面聚合及分子印迹技术制备了具有pH值/近红外光双响应性能的纳米智能药物载体CAP-MIP(capecitabine-imprinted polymers)。实验结果表明,CAP-MIP不仅具有较好的载药活性(吸附容量7.00 mg/g),而且还具有良好的吸附选择性(CAP选择性因子α为2.904)。当介质pH分别为1.2、6.8和8.3时,CAP的最大累积释放率分别为1.71%、41.84%和89.54%,药物释放的平衡时间分别为40 min、180 min和420 min。当介质pH为6.8,且伴有近红外光(λ=980 nm)照射时,目标材料仅180 min就能使CAP达到最大累积释放率96.21%。此外,CAP-MIP还具有良好的稳定性,经过7次吸附-解吸循环后,CAP-MIP载药量损失率仅为8.29%。 |
| 英文摘要: |
| By utilizing a broad-spectrum anticancer drug capecitabine CAP as the template, upconversion nanoparticle as the carrier, 3,5-dicarboxy-4-methylacrylic ester azobenzene and acrylated gelatin as the bifunctional monomers, N,N′-methylenebisacrylamide as the cross-linker, and ammonium persulfate as the initiator, a pH/near-infrared dual-responsive nano-intelligent drug carrier named CAP-MIP, was successfully synthesized. The synthesis process involved the surface polymerization and the molecular imprinting technique, and the experimental results revealed that CAP-MIP exhibited the outstanding drug-loading activity, with an adsorption capacity of 7.00 mg/g, and the remarkable adsorption selectivity (CAP selectivity factor α of 2.904). The maximum cumulative release rates of CAP at the media with pH values of 1.2,6.8, and 8.3 were 1.71%, 41.84%, and 89.54%, respectively, with the related equilibrium release time of 40 min, 180 min, and 420 min. Under the condition of pH 6.8 and NIR irradiation (λ=980 nm), CAP-MIP demonstrated a rapid release, reaching a maximum cumulative release rate of 96.21% with just 180 min. Furthermore, the stability of CAP-MIP was evident, with a drug loss rate of only 8.29% after seven adsorption-desorption cycles. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|