| 谭倪,王朵朵,柳立杰,叶俏荣,曾忱思,齐晨汐.抗干扰性智能索拉菲尼隐形印迹材料的制备及其释药性能研究[J].南华大学学报(自然科学版),2023,(3):71~80.[TAN Ni,WANG Duoduo,LIU Lijie,YE Qiaorong,ZENG Chensi,QI Chenxi.Preparation and Drug Release Performance of Smart Sorafenib Stealth Imprinted Material with Anti-interference Property[J].Journal of University of South China(Science and Technology),2023,(3):71~80.] |
| 抗干扰性智能索拉菲尼隐形印迹材料的制备及其释药性能研究 |
| Preparation and Drug Release Performance of Smart Sorafenib Stealth Imprinted Material with Anti-interference Property |
| 投稿时间：2022-12-23 |
| DOI： |
| 中文关键词: 抗干扰性 索拉菲尼 隐形印迹材料 智能药物载体〖PS23-03谭倪OSID码.tif Y4*4,Y#〗 |
| 英文关键词:anti-interference sorafenib stealth imprinted material smart drug carrier |
| 基金项目:湖南省自然科学基金项目(2020JJ4520) |
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| 中文摘要: |
| 将分子印迹技术和隐形纳米技术相结合,用亲水性聚乙二醇对索拉菲尼印迹聚合物进行隐形化修饰,制备了具有抗干扰性能的智能索拉菲尼隐形印迹材料。研究发现该材料对含NaCl、KCl盐溶液具有较好的抗干扰性,当Na+、K+分别与索拉菲尼共存时,目标材料对索拉菲尼的吸附容量仅下降8.6%及19.2%。不仅如此,目标材料还对索拉菲尼现出良好的特异选择性,相对瑞戈非尼和甜菜碱而言,其分离因子各为2.33、4.63。释药性能结果表明,目标材料不仅在模拟肿瘤环境(pH为5.5)的累积释药率41.42%要明显高于在正常生理环境(pH为7.4)条件下的27.71%,而且于还原性物质谷胱甘肽存在的情况下,无论pH值为5.5还是7.4时,目标材料的药物累积释放率均显著增大,分别为63.77%及39.15%。目标印迹材料对索拉菲尼的缓释效果也不错,时长可达160 h。 |
| 英文摘要: |
| Combining molecular imprinting technology with stealth nanotechnology, sorafenib imprinted polymer was stealthly modified by hydrophilic polyethylene glycol, and an intelligent sorafenib stealth imprinting material S-SMIP with anti-interference performance was prepared. It was found that this material had good anti-interference ability to salt solution. When Na+ and K+ coexist with sorafenib, the adsorption capacity of sorafenib decreased by only 8.6% and 19.2% respectively, and the specific selectivity was also high. The separation factors for regafinib and betaine were 2.33 and 4.63 respectively. In addition, the drug release rate of 41.42% in the simulated tumor environment at pH5.5 was significantly higher than that of 27.71% in the normal physiological environment at pH7.4, and the cumulative drug release rate increased significantly at pH5.5 and pH7.4 under reducing glutathione, which were 63.77% and 39.15% respectively. Sorafenib release time in S-SMIP was also good, up to 160 h. |
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