| 郦志阳,蒋敏,彭鹏程,苏昌霖,肖锡林.香豆素类衍生物的设计、合成及应用研究[J].南华大学学报(自然科学版),2018,32(3):84~89.[LI Zhiyang,JIANG Min,PENG Pengcheng,SU Changlin,XIAO Xilin.Study on Design,Synthesis and Application of Coumarin Derivatives[J].Journal of University of South China(Science and Technology),2018,32(3):84~89.] |
| 香豆素类衍生物的设计、合成及应用研究 |
| Study on Design,Synthesis and Application of Coumarin Derivatives |
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| DOI： |
| 中文关键词: 荧光探针 香豆素类衍生物 Cr3+ 配位 |
| 英文关键词:fluorescent probe coumarin derivatives Cr3+ coordination |
| 基金项目:国家自然科学基金项目(11475079) |
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| 中文摘要: |
| 香豆素及其衍生物具有很强荧光性.香豆素类荧光探针广泛应用于药物开发、疾病监测、金属离子检测等.随着工业化的发展,越来越多的有毒金属离子存在于我们生活环境之中,如何快速有效地识别金属离子显得尤为重要.用4-甲基-8-甲酰基-7-羟基香豆素、2-氨甲基吡啶反应合成了一种能够识别Cr3+的新型荧光分子探针MFHC.当溶液为乙腈时该配体对Cr3+具有高度的选择性识别作用,并且当其他离子在高于Cr3+浓度5倍的情况下该配体仍具有较强的抗干扰能力.荧光滴定实验表明:主体与配体之间的配位比应为1∶1,检测限为1.19×10-11μmol /L. |
| 英文摘要: |
| Coumarin and its derivatives are highly fluorescent.Coumarin fluorescent probes are widely used in drug development,disease monitoring,and metal ion detection.With the development of industrialization,more and more toxic metal ions are present in our living environment.It is particularly important to identify metal ions efficiently and quickly.In this paper,a novel fluorescent molecular probe MFHC capable of recognizing Cr3+ was synthesized from 4-methyl-8-formyl-7-hydroxycoumarin and 2-aminomethylpyridine.When the solution is acetonitrile,the ligand has a high selective recognition effect on Cr3+,and the ligand still has a strong anti-interference ability when the other ions are higher than the Cr3+ concentration by 5 times.The fluorescence titration experiments show that the coordination ratio between host and ligand should be 1∶1,and the detection limit was 1.19×10-11μmol/L. |
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