| 魏传晚,王晓娟,何军.二茂铁-肽Fc-Lys-Leu-Val-OCH3的合成及电化学性质[J].南华大学学报(自然科学版),2015,29(3):92~95, 98.[WEI Chuan-wan,WANG Xiao-juan,HE Jun.Synthesis and Electrochemical Property of Ferrocene-peptide Fc-Lys-Leu-Val-OCH3[J].Journal of University of South China(Science and Technology),2015,29(3):92~95, 98.] |
| 二茂铁-肽Fc-Lys-Leu-Val-OCH3的合成及电化学性质 |
| Synthesis and Electrochemical Property of Ferrocene-peptide Fc-Lys-Leu-Val-OCH3 |
| 投稿时间：2015-01-16 |
| DOI： |
| 中文关键词: 二茂铁-肽 液相合成 电化学 |
| 英文关键词:ferrocene-peptide solution phase synthesis electrochemistry |
| 基金项目: |
|
| 摘要点击次数: 777 |
| 全文下载次数: 692 |
| 中文摘要: |
| 以二茂铁、亮氨酸、缬氨酸和赖氨酸为原料,苯并三唑-1-四甲基六氟磷酸酯(HBTU)及1-羟基苯并三唑(HOBt)为缩合剂,采用液相合成法,合成了Fc-Lys-Leu-Val-OCH3(简称Fc-KLV,其中Fc:ferrocenoyl,二茂铁).用柱层析分离纯化得到目标化合物,并对目标化合物进行紫外和核磁表征以确证其结构.Fc-KLV的循环伏安扫描结果表明,在0.4～0.8 V范围内出现了一对可逆的氧化还原峰,氧化峰和还原峰电位分别为624 mV和546 mV,峰电位之差ΔEp为78 mV,峰电流密度之比Ipa/Ipc=1.12,扩散系数D=1.782×10-6 cm2/s,表明相应的电化学过程主要受扩散控制. |
| 英文摘要: |
| Electrochemical peptide Fc-Lys-Leu-Val-OCH3(Fc-KLV,Fc:ferrocenoyl) was synthesized from ferrocene,Leu,Val and Lys by solution phase peptide synthesis method using O-(benzotriazol-yl)-N,N,N′,N′-tetramethyluronium (HBTU)/1-hydroxybenzotrizole (HOBt) as coupling reagents.The crude Fc-peptide was purified by column chromatography,and then was characterized by UV and NMR.The formal redox potential,Epa and Epc at 624 mV and 546 mV,respectively,and Ipa/Ipc at 1.12 were characteristic for the Fc-peptide undergoing a one-electron redox process.These results suggested that the electrochemical process is mainly controlled by the diffusion. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|