| 郑友霖,肖新荣,王皖,徐秋燕,唐小敏,郭倩.间二氟吗啉醇衍生物分子设计、合成及抗实验性抑郁活性研究[J].南华大学学报(自然科学版),2014,28(4):97~101.[ZHENG You-lin,XIAO Xin-rong,WANG Wan,XU Qiu-yan,TANG Xiao-min,GUO Qian.Molecule Design,Synthesis and Antidepressive Activity ofM-difluorinemorpholinol Derivatives[J].Journal of University of South China(Science and Technology),2014,28(4):97~101.] |
| 间二氟吗啉醇衍生物分子设计、合成及抗实验性抑郁活性研究 |
| Molecule Design,Synthesis and Antidepressive Activity ofM-difluorinemorpholinol Derivatives |
| 投稿时间：2014-03-05 |
| DOI： |
| 中文关键词: 间二氟吗啉醇 合成 抗抑郁 |
| 英文关键词:M-difluorinemorpholinol synthesis antidepressant |
| 基金项目:湖南省科技厅基金资助项目(04SK3053-3) |
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| 中文摘要: |
| 以3,5-二氟苯腈为起始原料与乙基溴化镁反应合成的3,5-二氟苯丙酮,经过溴代、胺化、环合、酸化反应,合成4个间二氟吗啉醇盐酸盐化合物,目标化合物的结构经1H NMR,IR和MS分析确证,利用小鼠强迫游泳抗抑郁药理模型对所合成的化合物进行抗抑郁药理活性试验.结果表明,目标化合物Ⅵ4 具有一定的抗抑郁活性. |
| 英文摘要: |
| In this paper,3,5-difluoropropiophenone is synthetised using 3,5-difluorine benzene nitriles as the raw material reaction with ethyl magnesium bromide.Starting from 3,5-difluoropropiophenone,the four m-difluorine morpholinol hydrochloride are synthetised via several steps including bromination,amination,cyclization and acidification.Using the forced swim mice model of antidepressant pharmacology,the pharmacological effects of antidepressant of the synthesized compounds were observed.The target compound is synthetised and its structure is proved by 1H NMR,IR and MS.Results show that compound Ⅵ4 have potent antidepressant activities. |
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