| 孙允凯，阳鹏飞，梁俊，陈民.2,2′-联咪唑并［5,6-f］邻菲罗啉及其铜配合物的合成[J].南华大学学报(自然科学版),2013,27(4):82~85.[SUN Yun-kai,YANG Peng-fei,LIANG Jun,CHEN Min.The Synthesis of 2,2′-bisglyoxaline［5,6-f］phenanthroline and its Copper Complexes[J].Journal of University of South China(Science and Technology),2013,27(4):82~85.] |
| 2,2′-联咪唑并［5,6-f］邻菲罗啉及其铜配合物的合成 |
| The Synthesis of 2,2′-bisglyoxaline［5,6-f］phenanthroline and its Copper Complexes |
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| DOI： |
| 中文关键词: 1,10-邻菲罗啉-5,6-二酮 2-醛基咪唑 合成 配合物 |
| 英文关键词:1,10-phenanthroline-5,6-dione 2-imidazolecarboxaldehyde synthesis complex |
| 基金项目:国家自然科学基金资助项目（11305086）;博士启动基金资助项目（2011XQD55） |
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| 中文摘要: |
| 邻菲罗啉衍生物的金属配合物对于DNA具有键合作用，有助于研发抗癌新药.以1,10-邻菲罗啉为原料合成了1,10-邻菲罗啉-5,6-二酮，然后与2-咪唑醛和醋酸铵在冰乙酸的环境下加热回流3.5 h，得到产品2,2′-联咪唑并［5,6-f］邻菲罗啉.将该产物与硝酸铜配位，制得铜配合物.用NMR、元素分析和IR对产物进行了表征.该目标产物有可能对DNA的切割起作用。 |
| 英文摘要: |
| The metal complexes of phenanthroline ramification can bind to DNA through noncovalent interactions,which will help develop new anticancer drugs.1,10-phenanthroline-5,6-dione （DIONE） was synthesized by oxidation of 1,10-Phenanthroline.2,2′-bisglyoxaline［5,6-f］phenanthroline （BGP） was then obtained by heating the mixture of DIONE / 2-imidazolecarboxaldehyde / ammonium acetate and glacial acetic acid to reflux.At last,copper complex of BGP was obtained by coordination reaction,which was BGP characterized by IR,and all products were characterized by elemental analysis,NMR spectroscopy and IR.The target product may have activity on DNA. |
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