| 夏岳韬,肖新荣*,王英,贾小鹏,陈川.3-甲基-5-苯基-(2-氟苯基)-2-吗啉醇盐酸盐的合成[J].南华大学学报(自然科学版),2011,25(4):102~104.[XIA Yue-tao,XIAO Xin-rong*,WANG Ying,JIA Xiao-peng,CHEN Chuan.Synthesis of 3-methyl-5-phenyl-（2-difluorophenyl)-2-morpholinol Hydrochloride[J].Journal of University of South China(Science and Technology),2011,25(4):102~104.] |
| 3-甲基-5-苯基-(2-氟苯基)-2-吗啉醇盐酸盐的合成 |
| Synthesis of 3-methyl-5-phenyl-（2-difluorophenyl)-2-morpholinol Hydrochloride |
| 投稿时间：2011-09-25 |
| DOI： |
| 中文关键词: 1-（2-氟苯基）-2-溴-1-丙酮 苯甘氨醇 吗啉醇盐酸盐 合成 |
| 英文关键词:1-(2-difluorophenyl)-2-bromo-1-Acetone Phenylglycinol morpholinol hydrochloride synthesis |
| 基金项目:湖南省科技厅基金资助项目（04SK3053-3） |
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| 中文摘要: |
| 以安非他酮在人体内的活性代谢物羟基安非他酮为先导化合物，利用1-（2-氟苯基）-2-溴-1-丙酮和苯甘氨醇在NMP溶剂中反应，经胺化、环合、酸化合成得到了吗啉环上5位含苯基的新型吗啉醇类化合物.总收率70.3%，新化合物结构经IR、1H NMR、MS确证.该化合物在国内外未见报道.整个合成路线具有反应时间短，条件温和、收率高等优点. |
| 英文摘要: |
| 3-methyl-5-phenyl-（2-difluorophenyl)-2-morpholinol Hydrochloride was synthesized from 1-(2 -difluorophenyl)-2-bromo -1-Acetone and Phenylglycinol in polar solvents NMP by amine,cyclization reaction,reduction and acidification.The yield amounted to 70.3%.The structures of the target compounds were confirmed by means of IR,1H NMR and MS spectra.This new compound has never been reported at home and abroad.The synthesis method in the article has advantages of shortening reaction time,mild conditions and high yield. |
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