| 贾小鹏,肖新荣*,梁俊,夏岳韬,陈川,郭娅楠.3-甲基-2-(3-氯基苯基)吗啉盐酸盐的合成及其抗实验性抑郁活性[J].南华大学学报(自然科学版),2010,24(4):87~90.[JIA Xiao-peng,XIAO Xin-rong*,LIANG Jun,XIA Yue-tao,CHEN Chuan,GUO Ya-nan.Synthesis and Antidepressive Activity of 3-methyl-2-（3-chlorophenyl）Morpholine Hydrochloride[J].Journal of University of South China(Science and Technology),2010,24(4):87~90.] |
| 3-甲基-2-(3-氯基苯基)吗啉盐酸盐的合成及其抗实验性抑郁活性 |
| Synthesis and Antidepressive Activity of 3-methyl-2-（3-chlorophenyl）Morpholine Hydrochloride |
| 投稿时间：2010-10-27 |
| DOI： |
| 中文关键词: 乙醇胺 吗啉盐酸盐 合成 抗抑郁活性 |
| 英文关键词:ethanolamine morpholine hydrochloride synthesis antidepressive |
| 基金项目:湖南省科技厅基金资助项目（04SK3053-3） |
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| 中文摘要: |
| 以1-（3-氯基苯基）-2-溴-1-丙酮和乙醇胺为原料,经胺化、环合反应、还原,最后酸化得新型吗啉化合物（2）:3-甲基-2-(3-氯基苯基)吗啉盐酸盐,产率67.2 %,目标化合物结构经IR、1H NMR、MS测试技术确证,该化合物的合成在国内外从未见有过报道.利用小鼠强迫游泳抗抑郁药理模型对所合成的化合物进行抗抑郁药理活性观察.结果显示此化合物(2)具有一定的抗抑郁活性,值得进一步研究. |
| 英文摘要: |
| 3-methyl-2-(3-chlorophenyl) morpholinhy drochloride was synthesized from 1-(3-chlorophenyl) -2-bromo -1 - Acetone and ethanolamine as raw material,in polar solvents by amine,cyclization reaction,reduction,at last acidification by divergent synthetic method,and the yield is 79.3%.The target compound structure was confirmed by IR,1H NMR,MS tec-hnology,and the synthesis of this compound had never been reported at home and abroad.Using the forced swim mice model of antidepressant pharmacology,the pharmacological effects of antidepressant of the synthesized compounds were observed.That compound (2) have potent antidepress activities,and are worth further development. |
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