| 谭倪,刘磊,佘志刚,林永成.南海红树林内源真菌#2240的四个格链孢酚类衍生物次级代谢产物研究[J].南华大学学报(自然科学版),2008,22(4):1~6.[TAN Ni1,2,LIU Lei3,SHE Zhi-gang2,LIN Yong-cheng2.Research on Four Alternariol Derivatives Produced by the Mangrove Endophytic Fungus #2240 from the South China Sea[J].Journal of University of South China(Science and Technology),2008,22(4):1~6.] |
| 南海红树林内源真菌#2240的四个格链孢酚类衍生物次级代谢产物研究 |
| Research on Four Alternariol Derivatives Produced by the Mangrove Endophytic Fungus #2240 from the South China Sea |
| 投稿时间：2008-04-02 |
| DOI： |
| 中文关键词: 红树林内源真菌 格链孢酚类衍生物 次级代谢产物 抑制活性 生源途径 |
| 英文关键词:mangrove endophytic fungus alternariol derivatives secondary metabolites inhibition activity biogenetic path |
| 基金项目:国家“863”课题资助项目(2006AA09Z422);国家自然科学基金资助项目(20072058);南华大学博士启动基金. |
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| 中文摘要: |
| 通过人工发酵培养,利用层析技术,首次从南海红树林内源真菌#2240的培养液中分离得到4个格链孢酚类衍生物次级代谢产物,它们分别是:4-甲氧基-10-乙酸格链孢酚酯(化合物1)、格链孢酚(化合物2)、4-甲氧基格链孢酚(化合物3)、4,10-二甲氧基格链孢酚(化合物4).其结构通过谱图分析(包括1H、13C NMR,DEPT,HMQC,HMBC,HREIMS,UV及IR等)和相关文献得以确定.初步药理实验表明,化合物2和3对KB和KBv200癌细胞具有较强活性,IC50值分别为3.17、3.12 μg/mL和4.82、4.94 μg/mL,化合物1和4对上述两种癌细胞的抑制活性较弱,IC50值均超过50 μg/mL.并且从生源途径角度也初步探索了上述四个化合物之间的相互关系. |
| 英文摘要: |
| Four alternariol derivatives,alternariol 4-methoxy-10-acetoxy ester(compound 1),alternariol(compound 2),alternariol monomethyl ether(compound 3),and alternariol 4,10-dimethyl ether(compound 4),were isolated from the culture media of mangrove endophytic fungus #2240 collected from a mangrove Castaniopsic Fissa at the South China Sea coast through chromatographic separation.Their structures were unambiguously elucidated by the related literatures and the spectral analysis including 1H，13C NMR,DEPT,HMQC,HMBC,HREIMS,IR,and UV.The anticancer tests showed that compound 2 and 3 had strong activities against KB and KBv200 cells with IC50 values of 3.17,3.12 and 4.82,4.94 μg/mL,while compound 1 and 4 exhibited weak activities against the two kinds of tumor lines with IC50 values of more than 50 μg/mL.In addition,the plausible biogenetic path for compound 1,2,3 and 4 were also discussed. |
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