CMV-PP65抗原检测在预防肾移植术后巨细胞病毒感染的临床价值
The clinical value of CMV-PP65 antigen detection in the prevention of cytomegalovirus infection after renal transplantation
投稿时间:2013-09-09  修订日期:2013-11-10
DOI:
中文关键词:  肾移植  巨细胞病毒PP65  巨细胞病毒IgM抗体
英文关键词:Renal transplantation  Cytomegalovirus PP65  Cytomegalovirus IgM antibody
基金项目:衡阳市科委资助课题(编号:2008KS022)
作者单位E-mail
谭湘芳 南华大学第二附属医院检验科 xiaofeng29@163.com 
罗志刚 南华大学第二附属医院肾移植科  
王毅 南华大学第二附属医院肾移植科  
李建军 南华大学第二附属医院肾移植科  
钱坤 南华大学第二附属医院肾移植科  
李跃进 南华大学第二附属医院检验科  
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中文摘要:
      目的 探讨巨细胞病毒PP65抗原(CMV-PP65)检测在预防肾移植术后巨细胞病毒(CMV)感染的临床价值。 方法 采用间接免疫荧光法和酶联免疫捕获法检测52例肾移植受者术后CMV-PP65抗原和CMV-IgM抗体。 结果 52例肾移植受者中CMV-PP65抗原检测阳性25例,CMV-IgM抗体检测阳性17例,随访3~6个月,共15例发生CMV病,CMV-PP65抗原检测均阳性,CMV-PP65抗原检测的敏感度及阴性预测值均高于CMV-IgM抗体检测;25例患者CMV-PP65抗原检测术后首次出现阳性的平均时间为(4.2±3.3)周,17例患者CMV-IgM抗体检测术后首次出现阳性的平均时间为(8.7±5.8)周,两者比较有显著差异性(P<0.05)。 结论 CMV-PP65抗原检测可早期排除和预防肾移植术后CMV感染,值得临床推广应用。
英文摘要:
      Abstract: objective To investigate the clinical value of CMV-PP65 antigen detection in the prevention of cytomegalovirus infection after renal transplantation. Methods The CMV-PP65 antigen and CMV-IgM antibody of 52 cases with renal transplantation recipients were detected with the method of indirect immunofluorescence and enzyme-linked immune capture. Results Among the 52 cases of kidney transplant, 25 were tested positive with CMV-PP65 antigen, 17 cases were tested positive with CMV-IgM antibody. All patients were followed up for 3~6 months, CMV occurred in 15 cases, and their CMV-PP65 antigen were detected positive, the detection sensitivity and negative predictive value of CMV-PP65 antigen detection were higher than that of CMV-IgM antibody detection. The average length for the first postsurgical positive detection of CMV-PP65 antigen with 25 cases was (4.2±3.3) weeks, while that of the CMV-IgM antibody with 17 cases was (8.7±5.8) weeks, with a significant difference between them (P<0.05). Conclusion CMV-PP65 antigen detection could be employed for the early elimination and prevention of CMV infection after renal transplantation. It was worthy of clinical popularization and application.
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