| 谭赛娟,彭华保,陈虹亮.肺炎链球菌对β-内酰胺类抗生素耐药机制的研究进展.[J].中南医学科学杂志.,2020,(4):342-345, 363. |
| 肺炎链球菌对β-内酰胺类抗生素耐药机制的研究进展 |
| Research progress of resistance mechanism of Streptococcus pneumoniae against β-lactams antibiotics |
| 投稿时间：2020-05-14 修订日期：2020-06-05 |
| DOI：10.15972/j.cnki.43-1509/r.2020.04.002 |
| 中文关键词: 肺炎链球菌 β-内酰胺类药物 耐药机制 |
| 英文关键词:Streptococcus pneumoniae β- lactams resistance mechanism |
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| 中文摘要: |
| 肺炎链球菌(Streptococcus pneumoniae)是儿童社区获得性感染最常见细菌病原体,严重危害人类健康。β-内酰胺类抗生素是治疗肺炎链球菌感染最常用的药物。自1928年英国细菌学家亚历山大·弗莱明发现世界上第一种抗生素—青霉素以来,人类越来越依赖于抗生素,从而导致抗生素长期过度使用,使得肺炎链球菌对β-内酰胺类抗生素的耐药性迅速增加,每年造成200万人死亡。本文拟从产β-内酰胺酶、青霉素结合蛋白基因的改变等方面综述肺炎链球菌对β-内酰胺类抗生素的耐药机制。 |
| 英文摘要: |
| Streptococcus pneumoniae is the most common bacterial pathogen of community acquired in children, being seriously harmful to human health.β- lactam antibiotics are the most frequently drugs used in the treatment of Streptococcus pneumoniae infection. Since the first antibiotic penicillin was discovered by Alexander Fleming-a British bacteriologist-in the world in 1928, people have become more and more dependent on antibiotics, resulting in the long-term overuse of antibiotics, the resistance of Streptococcus pneumoniae to β-lactam antibiotics increasing rapidly and more than 2 million deaths every year. In this paper, the mechanism of resistance of Streptococcus pneumoniae to β-lactamases was reviewed including β-lactamase production, the change of penicillin binding protein gene and so on. |
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