| 卢春娇.观察羟考酮联合瑞芬太尼对宫颈癌患者苏醒期镇痛、镇静情况的影响.[J].中南医学科学杂志.,2020,(1):28-31. |
| 观察羟考酮联合瑞芬太尼对宫颈癌患者苏醒期镇痛、镇静情况的影响 |
| Effects of oxycodone combined with remifentanil at the end of surgery on analgesia and sedation of patients with cervical cancer during recovery period |
| 投稿时间：2019-07-23 修订日期：2019-10-11 |
| DOI：10.15972/j.cnki.43-1509/r.2020.01.008 |
| 中文关键词: 羟考酮 瑞芬太尼 宫颈癌 腹腔镜术后 苏醒期镇痛 |
| 英文关键词:oxycodone remifentanil cervical cancer after laparoscopic surgery analgesia during recovery period |
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| 中文摘要: |
| 探讨羟考酮联合瑞芬太尼应用于宫颈癌术后苏醒期的镇痛效果。将92例宫颈癌患者均分为联合组与对照组各46例。对照组术毕前预用瑞芬太尼镇痛,联合组在对照组基础上联合给予羟考酮。临床结果显示拔管后5 min(T1)时,两组心率(HR)、平均动脉压(MAP)水平均较拔管即刻(T0)时有显著提升,且联合组明显低于对照组同一时间(均P＜0.05)；拔管后15 min(T2)、拔管后30 min(T3)时,联合组HR、MAP水平与T0时比较差异均无统计学意义(均P＞0.05),但均明显低于对照组同一时间(均P＜0.05)。T1、T2、T3时,两组呼吸频率(RR)、血氧饱和度(SpO2)水平均较T0时显著提升(均P＜0.05)。T3时,联合组疼痛程度[视觉模拟法疼痛评分(VAS)]明显低于对照组,镇静程度(Ramsay镇静评分)2～3分率明显高于对照组(均P＞0.05)。结果表明术毕前应用羟考酮注射液联合瑞芬太尼能维持宫颈癌腹腔镜术后患者血流动力学平稳,安全且有效地达到苏醒期镇痛与镇静效果,有利于改善其麻醉体验。 |
| 英文摘要: |
| To investigate the analgesic effects of oxycodone combined with remifentanil in the recovery period after cervical cancer surgery. 92 patients with cervical cancer were divided into combined group and control group, with 46 cases in each group. Control group was pre-administered with remifentanil analgesia before the end of surgery, and combined group was combined with oxycodone on this basis. The results showed that At t1, the levels of HR and MAPin the two groups were significantly higher than those at T0, and the levels in combined group were significantly lower than those in control group at the same time (P<0.05). At T2 and T3, there were no statistically significant differences in the levels of HR and MAP in combined group compared with those at T0 (all P>0.05), but the levels were significantly lower than those in control group at the same time (all P<0.05). At T1, T2 and T3, the levels of RR and SpO2 in the two groups were significantly higher than those at T0 (all P<0.05), but there were no significant differences between the two groups at the same time (all P>0.05). At T3, the VAS score in combined group was significantly lower than that in control group, and the Ramsay score of 2 to 3 points was significantly higher than that in control group (all P>0.05). So Pre-administration of oxycodone injection combined with remifentanil before the end of surgery can maintain the hemodynamic stabilization of patients with cervical cancer after laparoscopic surgery, and it can safely and effectively achieve analgesic and sedative effects during recovery period, and it is beneficial to improve the anesthesia experience. |
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