| 乔秋芳,王亮,陈丽.血清Th17/Treg细胞因子对血液肿瘤患者血小板输注无效的预测价值.[J].中南医学科学杂志.,2026,(1):83-86. |
| 血清Th17/Treg细胞因子对血液肿瘤患者血小板输注无效的预测价值 |
| Predicting value of serum Th17/Treg cytokines on platelet transfusion refractoriness in patients with hematological malignancies |
| 投稿时间：2025-03-03 修订日期：2025-10-27 |
| DOI：10.15972/j.cnki.43-1509/r.2026.01.019 |
| 中文关键词: 血清 Th17/Treg细胞因子 血液肿瘤 血小板输注无效 |
| 英文关键词:serum Th17/Treg cytokines hematological malignancies PTR |
| 基金项目:河北省卫生健康委资助项目(20232118) 作者简介:乔秋芳,主管技师,研究方向为临床输血,检验医学,医学实验室质量管理,E-mail为qqf2025@163.com。 |
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| 中文摘要: |
| 目的探讨血清辅助性T细胞17(Th17)/调节性T细胞(Treg)因子对血液肿瘤患者血小板输注无效(PTR)的预测价值。 方法选取本院治疗的220例连续2次以上输注血小板的血液肿瘤患者作为研究对象,根据患者血小板输注效果,将其分为有效组(n＝151)和无效组(n＝69)。采用单因素、二元Logistic回归模型分析血液肿瘤患者发生PTR的影响因素。采用ROC曲线评价血清Th17/Treg细胞因子对血液肿瘤患者发生PTR的预测价值。对Th17/Treg最佳截断值进行亚组分析,利用Spearman相关性分析Th17/Treg与其相关细胞因子的相关性。 结果有效组与无效组白细胞介素(IL)-6、IL-17、IL-10、转化生长因子β(TGF-β)、Th17、Treg、Th17/Treg比较,差异有统计学意义(P＜0.05)。IL-10、Th17/Treg是血液肿瘤患者发生PTR的影响因素(P＜0.05)。ROC曲线分析结果显示,Th17/Treg预测PTR的AUC为0.923。Th17/Treg≥0.54患者有效率高于Th17/Treg＜0.54者(P＜0.05)。Th17/Treg与IL-17呈负相关(P＜0.05),与IL-6、IL-10、TGF-β呈正相关(P＜0.05)。 结论血清Th17/Treg细胞因子对血液肿瘤患者PTR具有较高的预测价值。 |
| 英文摘要: |
| AimTo explore the predictive value of serum helper T cell 17 (Th17)/regulatory T cell (Treg) factors for platelet transfusion refractoriness (PTR) in patients with hematological malignancies. MethodsTotally 220 blood tumors patients who received two or more consecutive platelet transfusions in our hospital were selected as the research subjects. According to the platelet transfusion effect of the patients, they were divided into an effective group (n＝151) and an ineffective group (n＝69). Single factor and binary Logistic regression analysis were adopted to investigate the influencing factors of PTR in patients with hematological malignancies. ROC curve were used to evaluate the predictive value of serum Th17/Treg related cytokines for PTR in patients with hematological malignancies. Subgroup analysis on the best cutoff values of Th17/Treg was performed and Spearman correlation analysis was used to analyze the correlations between Th17/Treg and its related cytokines. ResultsThere were statistically significant differences in the levels of interleukin(IL)-6, IL-17, IL-10, transforming growth factor beta (TGF-β), Th17, Treg, and Th17/Treg between the effective group and the ineffective group (P＜0.05). IL-10 and Th17/Treg were influencing factors of PTR in patients with hematological malignancies (P＜0.05). The ROC analysis results showed that the AUC of Th17/Treg for predicting PTR was 0.923. The effective rate of Th17/Treg ≥0.54 patients was higher than that of Th17/Treg ＜0.54 patients (P＜0.05). Th17/Treg was negatively correlated with IL-17 (P＜0.05), and positively correlated with IL-6, IL-10, and TGF-β (P＜0.05). ConclusionSerum Th17/Treg cytokines have high predictive value for PTR in patients with hematological malignancies. |
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