| 张根生,张娟,郑琎喆,刘杨洋,张波.血清t-PINP/β-CTX比值对OVCF患者术后骨折延迟愈合的预测作用.[J].中南医学科学杂志.,2026,(1):59-62. |
| 血清t-PINP/β-CTX比值对OVCF患者术后骨折延迟愈合的预测作用 |
| The predictive value of serum t-PINP/β-CTX ratio for delayed fracture healing after surgery in patients with OVCF |
| 投稿时间：2024-12-18 修订日期：2025-11-05 |
| DOI：10.15972/j.cnki.43-1509/r.2026.01.013 |
| 中文关键词: t-PINP β-CTX OVCF 骨折延迟愈合 预测价值 |
| 英文关键词:t-PINP β-CTX OVCF delayed fracture healing predictive value |
| 基金项目:国家临床重点专科建设项目经费资助(陕卫医政函〔2023〕325号) 作者简介:张根生,硕士,副主任医师,研究方向为骨科、创面修复,E-mail为zgs215325637@163.com。通信作者张娟,硕士,副主任医师,研究方向为内分泌代谢性疾病,E-mail为zhangjmao@163.com。 |
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| 中文摘要: |
| 目的探讨总Ⅰ型胶原氨基端延长肽(t-PINP)/Ⅰ型胶原羧基端肽B特殊序列(β-CTX)比值对骨质疏松性椎体压缩性骨折(OVCF)患者术后骨折延迟愈合的预测作用。 方法选择OVCF患者106例,根据愈合情况分为愈合组70例与延迟组36例,比较两组血清t-PINP、β-CTX及t-PINP/β-CTX水平。采用多因素Logistic回归分析影响骨折延迟愈合的因素。采用ROC曲线分析t-PINP/β-CTX对骨折延迟愈合的预测价值。 结果延迟组年龄、Cobb角高于愈合组,骨密度低于愈合组(P＜0.05)。延迟组血清t-PINP高于愈合组,β-CTX低于愈合组,t-PINP/β-CTX高于愈合组(P＜0.05)。年龄、骨密度、t-PINP/β-CTX是OVCF患者术后骨折延迟愈合的影响因素(P＜0.001)。t-PINP/β-CTX对OVCF患者术后骨折延迟愈合的诊断效能高于t-PINP、β-CTX(P＜0.001)。 结论t-PINP/β-CTX是OVCF患者术后骨折延迟愈合的影响因素,t-PINP/β-CTX越高发生骨折延迟愈合的风险越高,临床可根据t-PINP/β-CTX判断其风险并制定相关治疗策略。 |
| 英文摘要: |
| AimTo investigate the predictive value of the total type I procollagen amino-terminal propeptide (t-PINP)/β-C-terminal telopeptide of type I collagen (β-CTX) ratio for delayed fracture healing after surgery in patients with osteoporotic vertebral compression fracture (OVCF). MethodsA total of 106 OVCF patients were selected and divided into a healing group (n＝70) and a delayed healing group (n＝36) based on their healing status. Serum t-PINP, β-CTX levels, and the t-PINP/β-CTX ratio were compared between the two groups. Multivariate logistic regression analysis was used to identify factors influencing delayed fracture healing. The predictive value of the t-PINP/β-CTX ratio for delayed fracture healing was analyzed using receiver operating characteristic (ROC) curves. ResultsThe delayed healing group had a higher age and Cobb angle, and a lower bone mineral density compared with the healing group (P＜0.05). The delayed healing group showed higher serum t-PINP levels, lower β-CTX levels, and a higher t-PINP/β-CTX ratio than the healing group (P＜0.05). Age, bone mineral density, and the t-PINP/β-CTX ratio were identified as influencing factors for delayed fracture healing after surgery in OVCF patients (P＜0.001). The t-PINP/β-CTX ratio demonstrated superior diagnostic efficacy for delayed fracture healing compared with t-PINP or β-CTX alone (P＜0.001). ConclusionThe t-PINP/β-CTX ratio is an influencing factor for delayed fracture healing after surgery in OVCF patients. A higher t-PINP/β-CTX ratio is associated with an increased risk of delayed fracture healing. Clinically, the t-PINP/β-CTX ratio can be used to assess this risk and formulate relevant treatment strategies. |
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