| 严方涛,王真,汤兰兰,沈剑.AECOPD合并呼吸衰竭患者血清IL-6、HBP、25-(OH)D水平与预后的关系.[J].中南医学科学杂志.,2026,(1):55-58. |
| AECOPD合并呼吸衰竭患者血清IL-6、HBP、25-(OH)D水平与预后的关系 |
| Relationship between serum IL-6, HBP, 25-(OH)D levels and prognosis in AECOPD patients with respiratory failure |
| 投稿时间：2024-12-23 修订日期：2025-11-10 |
| DOI：10.15972/j.cnki.43-1509/r.2026.01.012 |
| 中文关键词: AECOPD 呼吸衰竭 白细胞介素-6 肝素结合蛋白 25-羟基维生素D |
| 英文关键词:AECOPD respiratory failure interleukin-6 heparin binding protein 25-hydroxyvitamin D |
| 基金项目:国家卫生健康委医药卫生科技发展研究中心课题(WKZX2023K0123) 作者简介:严方涛,硕士,副主任医师,研究方向为呼吸重症与呼吸介入,E-mail为15881158706@163.com。通信作者沈剑,副主任医师,硕士研究生导师,研究方向为呼吸危重症与呼吸康复,E-mail为Sjfy12@163.com。 |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的探讨急性加重期慢性阻塞性肺疾病(AECOPD)合并呼吸衰竭患者血清白细胞介素-6(IL-6)、肝素结合蛋白(HBP)及25-羟基维生素D[25-(OH)D]水平与预后的关系。 方法选取80例AECOPD合并呼吸衰竭患者,根据治疗后28天患者病情转归将其分为预后良好组(n＝53)和预后不良组(n＝27)。比较入院时两组患者COPD评估测试(CAT)评分和血清IL-6、HBP、25-(OH)D水平,分析IL-6、HBP、25-(OH)D水平与CAT评分的相关性。采用ROC曲线评估各指标对预后的评估价值。 结果两组性别、年龄、病程、合并基础病和吸烟史占比比较,差异无统计学意义(P＜0.05)。预后不良组IL-6、HBP和CAT评分高于预后良好组,25-(OH)D水平低于预后良好组(P＜0.05)。患者CAT评分与血清IL-6和HBP水平呈正相关(P＜0.05),与25-(OH)D水平呈负相关(P＜0.05)。ROC曲线分析结果显示,IL-6、HBP和25-(OH)D对AECOPD合并呼吸衰竭患者预后不良,均具有较高评估价值(P＜0.05)。 结论AECOPD合并呼吸衰竭患者血清IL-6、HBP及25-(OH)D水平与其疾病严重程度密切相关,且上述指标水平检测对预后评估具有较高价值。 |
| 英文摘要: |
| AimTo investigate the relationship between serum interleukin-6 (IL-6), heparin-binding protein (HBP), 25-hydroxyvitamin D (25-(OH)D) levels and prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure. MethodsA total of 80 AECOPD patients with respiratory failure were selected.According to the outcome 28 days after treatment, they were divided into a good prognosis group (n＝53) and a poor-prognosis group (n＝27). The COPD assessment test (CAT) scores and serum levels of IL-6, HBP, and 25-(OH)D at admission were compared between the two groups. The correlations of IL-6, HBP, and 25-(OH)D levels with CAT score were analyzed. The ROC curve was used to evaluate the value of each indicator in predicting prognosis. ResultsNo significant differences were found in gender, age, course of disease, proportion of underlying diseases, and smoking history between the two groups (P＞0.05). The poor-prognosis group had higher levels of IL-6, HBP, and CAT scores, but a lower level of 25-(OH)D compared with the good prognosis group (P＜0.05). The CAT score was positively correlated with serum IL-6 and HBP levels (P＜0.05), while negatively correlated with 25-(OH)D level (P＜0.05). ROC curve analysis results showed that IL-6, HBP, and 25-(OH)D all had high value in assessing poor prognosis in AECOPD patients with respiratory failure (P＜0.05). ConclusionSerum levels of IL-6, HBP, and 25-(OH)D in AECOPD patients with respiratory failure are closely related with the severity of the disease, and detecting these indicator levels has high value for prognosis assessment. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|