| 史方泽,江晨艳,康雪然,孙与幸,石润杰.基于网络药理学探讨百合固金汤治疗萎缩性鼻炎的作用机制.[J].中南医学科学杂志.,2026,(1):14-19. |
| 基于网络药理学探讨百合固金汤治疗萎缩性鼻炎的作用机制 |
| Exploring the mechanism of Baihe Gujin Decoction in treating atrophic rhinitis based on network pharmacology |
| 投稿时间：2025-07-09 修订日期：2025-11-28 |
| DOI：10.15972/j.cnki.43-1509/r.2026.01.003 |
| 中文关键词: 萎缩性鼻炎 百合固金汤 网络药理学 |
| 英文关键词:atrophic rhinitis Baihe Gujin Decoction network pharmacology |
| 基金项目:中央高校基本科研业务费专项资金资助(YG2021ZD16) 作者简介:史方泽,硕士,研究方向为耳鼻疾病的诊治,E-mail为sfz_9htg@163.com。通信作者石润杰,博士,主任医师,研究方向为耳鼻喉各类疾病及组织工程应用,E-mail为shirunjie9h@163.com。 |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的基于网络药理学探讨百合固金汤治疗萎缩性鼻炎(AR)的作用机制。 方法从TCMSP、GeneCard等数据库、AR疾病靶点数据库及差异蛋白组学结果中筛选百合固金汤的活性成分及潜在靶点,构建药物-活性成分-潜在靶点交互网络。采用京都基因与基因组百科全书(KEGG)及基因本体论(GO)富集分析潜在交集靶点。利用分子对接与分子动力学模拟验证活性成分与核心靶点的结合能力。 结果筛选出百合固金汤的活性成分包括β-谷甾醇、槲皮素、山奈酚等113个,药物靶点837个,AR靶点743个,潜在交集靶点123个。GO功能富集结果显示,百合固金汤的靶点显著富集于对脂多糖的反应、对氧化应激的反应、细胞因子活性等条目；KEGG通路分析识别出163条相关通路,其中富集靠前的显著通路包括脂质和动脉粥样硬化、流体剪切应力和动脉粥样硬化。凝血因子XIII A链编码基因(F13A1)是药物靶点、疾病靶点与差异蛋白组学结果的共同交集靶点。F13A1与百合固金汤中槲皮素具有最强结合能力。 结论百合固金汤治疗AR的作用机制,可能与其富含的β-谷甾醇、槲皮素、山奈酚等活性成分,以多靶点、多通路机制缓解炎症、改善血管微循环,从而抑制黏膜萎缩与骨质吸收有关。 |
| 英文摘要: |
| AimTo explore the mechanism of Baihe Gujin Decoction in treating atrophic rhinitis (AR) based on network pharmacology. MethodsThe active ingredients and potential targets of Baihe Gujin Decoction were screened from TCMSP, GeneCards and other drug and AR disease target database,and differential proteomics results. An interaction network of drug-active ingredient-potential target was constructed. Potential intersecting targets were enriched and analyzed using Kyoto encyclopedia of genes and genomes (KEGG) and gene ontology (GO). The binding ability between the active ingredient and the core target were verified through molecular docking and molecular dynamics simulation. ResultsThe active ingredients of Baihe Gujin Decoction were screened, including 113 types such as β-sitosterol, quercetin, and kaempferol, with 837 potential drug targets, 743 AR targets, and 123 potential intersecting targets. The GO functional enrichment results showed that the targets of Baihe Gujin Decoction were significantly enriched in Go items such as lipopolysaccharide response, oxidative stress response, cytokine activity; The KEGG pathway analysis identified 163 related pathways, of which the top prominent pathways were lipid and atherosclerosis, fluid shear stress and atherosclerosis. Neutral sphingomyelinase (F13A1) was a common intersection target of drug targets, disease targets, and differential proteomics results. F13A1 has the strongest binding ability with quercetin in Baihe Gujin Decoction. ConclusionThe mechanism of action of Baihe Gujin Decoction in treating AR may be related to its rich active ingredients such as β-sitosterol, quercetin, and kaempferol, which alleviate inflammation and improve vascular microcirculation through multi-target and multi pathway mechanisms, thereby inhibiting mucosal atrophy and bone resorption. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|