| 谢玉,马雪燕,张韬.孟鲁司特钠联合重组人干扰素α-2b治疗毛细支气管炎患儿的效果及对细胞免疫的影响.[J].中南医学科学杂志.,2025,(6):1133-1136. |
| 孟鲁司特钠联合重组人干扰素α-2b治疗毛细支气管炎患儿的效果及对细胞免疫的影响 |
| Effects of montelukast sodium combined with recombinant human interferon α-2b on children with bronchiolitis and its influence on cellular immunity |
| 投稿时间：2024-11-15 修订日期：2025-05-20 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.048 |
| 中文关键词: 孟鲁司特钠 重组人干扰素α-2b 毛细支气管炎 细胞免疫 |
| 英文关键词:montelukast sodium rhIFNα-2b bronchiolitis cellular immunity |
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| 中文摘要: |
| 目的观察孟鲁司特钠联合重组人干扰素α-2b(rhIFNα-2b)治疗毛细支气管炎患儿的临床效果及对细胞免疫的影响。 方法将毛细支气管炎患儿144例随机分为观察组和对照组,每组72例。两组均接受抗感染、平喘、吸氧等基础治疗。对照组加用孟鲁司特钠,观察组在对照组基础上加用雾化吸入rhIFNα-2b,疗程7天。比较两组患儿的临床症状评分、外周血CD4＋CD183＋水平、血清炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、γ-干扰素诱导蛋白10(IP-10)、半胱氨酰白三烯(CysLTs)]水平及临床疗效。 结果治疗后,观察组患儿的咳嗽、三凹征评分和CD4＋CD183＋/CD4＋、CD4＋CD183＋/CD183＋比值,以及血清IL-6、TNF-α、IP-10、CysLTs水平均低于对照组(P＜0.05)。治疗后两组外周血白细胞水平降低(P＜0.05)。观察组的治疗总有效率高于对照组(P＜0.05)。 结论在基础治疗上联合应用孟鲁司特钠和rhIFNα-2b治疗毛细支气管炎患儿,能更有效地改善患儿临床症状,调节细胞免疫功能,减轻气道炎症反应,提高临床疗效。 |
| 英文摘要: |
| AimTo observe the clinical effects of montelukast sodium combined with recombinant human interferon α-2b (rhIFNα-2b) on children with bronchiolitis and its influence on cellular immunity. MethodsA prospective study was conducted based on 144 children with bronchiolitis, whom were randomly divided into an observation group and a control group, with 72 cases in each group. Both groups received basic treatment including anti-infection, asthma relief, and oxygen therapy. The control group was additionally treated with montelukast sodium, while the observation group received nebulized rhIFNα-2b based on the control group's treatment, for a course of 7 days. The clinical symptom scores, peripheral blood CD4＋CD183＋ levels, serum inflammatory factor levels [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interferon-γ-induced protein 10 (IP-10), cysteinyl leukotrienes (CysLTs)], and clinical efficacy were compared between the two groups. ResultsAfter treatment, the cough and three concave sign scores, the ratios of CD4＋CD183＋/CD4＋ and CD4＋CD183＋/CD183＋, and the serum levels of IL-6, TNF-α, IP-10, and CysLTs in the observation group were lower than those in the control group (P＜0.05). After treatment the levels of white blood cell in peripheral of the two groups decreased (P＜0.05). The total effective rate of the observation group was higher than that of the control group (P＜0.05). ConclusionBased on basic treatment, the combination of montelukast sodium and rhIFNα-2b can more effectively improve clinical symptoms, regulate cellular immune function, reduce airway inflammation, and enhance clinical efficacy in children with bronchiolitis. |
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