| 李缺缺,张瑞英,苏丽.依达拉奉联合乌司他丁对重症胰腺炎血液流变学、免疫球蛋白及淀粉酶的影响.[J].中南医学科学杂志.,2025,(6):1077-1080. |
| 依达拉奉联合乌司他丁对重症胰腺炎血液流变学、免疫球蛋白及淀粉酶的影响 |
| Effects of edaravone combined with ulinastatin on hemorheology, immunoglobulins, and amylase in severe acute pancreatitis |
| 投稿时间：2025-02-27 修订日期：2025-09-12 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.034 |
| 中文关键词: 依达拉奉 乌司他丁 重症胰腺炎 血液流变学 免疫球蛋白 淀粉酶 |
| 英文关键词:edaravone ulinastatin severe acute pancreatitis hemorheology immunoglobulins amylase |
| 基金项目:邢台市重点研发计划项目(2020ZC294) |
|
| 摘要点击次数: 46 |
| 全文下载次数: 22 |
| 中文摘要: |
| 目的观察依达拉奉联合乌司他丁对重症胰腺炎患者血液流变学、免疫球蛋白及淀粉酶的影响。 方法将本院收治的110例重症胰腺炎患者分为乌司他丁组(n＝55)和联合组(n＝55)。比较两组治疗总有效率、症状缓解状况、血液流变学、免疫球蛋白、炎症及肠黏膜屏障功能。 结果联合组治疗总有效率高于乌司他丁组(P＜0.05)；首次排便时间、腹痛缓解时间、血淀粉酶及尿淀粉酶恢复时间均短于乌司他丁组(P＜0.05)。治疗后,两组全血高切黏度、血小板黏附率、血浆黏度、白细胞介素-6、肿瘤坏死因子-α、内毒素及D-乳酸水平均降低(P＜0.05),且联合组低于乌司他丁组(P＜0.05)；两组免疫球蛋白(Ig)M、IgG及IgA水平均升高(P＜0.05),且联合组高于乌司他丁组(P＜0.05)。 结论依达拉奉联合乌司他丁治疗重症胰腺炎可有效改善患者血液流变学,减轻炎症反应,增强免疫功能,缩短淀粉酶恢复时间,保护肠黏膜屏障功能。 |
| 英文摘要: |
| AimTo observe the effects of edaravone combined with ulastatin on hemorheology, immunoglobulin, and amylase in patients with severe pancreatitis. MethodsTotally 110 patients with severe acute pancreatitis admitted to our hospital were divided into a ulinastatin group (n＝55) and a combination group (n＝55). The therapeutic total effective rate, symptom relief, hemorheology, immunoglobulins, inflammation, and intestinal mucosal barrier function were compared between the two groups. ResultsThe therapeutic total effective rate of the combination group was higher than that of the ulinastatin group (P＜0.05). The time to first defecation, abdominal pain relief time, serum amylase and urine amylase recovery time were all shorter in the combination group compared with the ulinastatin group (P＜0.05). After treatment, the whole blood high-shear viscosity, platelet adhesion rate, plasma viscosity, interleukin-6, tumor necrosis factor-α, endotoxin, and D-lactic acid levels in both groups were decreased (P＜0.05), while their levels in the combination group were lower than those in the ulinastatin group (P＜0.05). The levels of immunoglobulin (Ig)M, IgG and IgA in both groups were increased (P＜0.05), and their levels in the combination group were higher than those in the ulinastatin group (P＜0.05). ConclusionUsing edaravone combined with ulinastatin for the treatment of severe acute pancreatitis can effectively improve hemorheology, reduce inflammatory response, enhance immune function, shorten amylase recovery time, and protect intestinal mucosal barrier function. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|