| 胡建生,杨中波,杨明龙,沈超.AECOPD合并呼吸衰竭患者血栓四项、血管生成抑制蛋白-1和铁蛋白水平及其临床意义.[J].中南医学科学杂志.,2025,(6):1073-1076. |
| AECOPD合并呼吸衰竭患者血栓四项、血管生成抑制蛋白-1和铁蛋白水平及其临床意义 |
| Levels and clinical significance of thrombus four items, VASH-1, and ferritin in AECOPD patients with respiratory failure |
| 投稿时间：2024-08-11 修订日期：2024-12-20 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.033 |
| 中文关键词: 血栓四项 血管生成抑制蛋白-1 血清铁蛋白 慢性阻塞性肺疾病急性加重期 呼吸衰竭 |
| 英文关键词:thrombus four items VASH-1 serum ferritin acute exacerbation of chronic obstructive pulmonary disease respiratory failure |
| 基金项目:合肥市卫生健康应用医学研究项目(Hwk2022zc046) |
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| 中文摘要: |
| 目的评估慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭患者血栓四项[凝血酶-抗凝血酶复合物(TAT)、纤溶酶-α2纤溶酶抑制剂复合物(PIC)、血栓调节蛋白(TM)、组织型纤溶酶原激活物-抑制剂复合物(t-PAIC)]、血管生成抑制蛋白-1(VASH-1)及血清铁蛋白(SF)的水平,并探讨其与患者病情严重程度及预后的关联与临床价值。 方法选择AECOPD合并呼吸衰竭患者80例作为观察组,单纯AECOPD患者80例作为对照组,比较两组血清TAT、PIC、TM、t-PAIC、VASH-1和SF水平,分析观察组中不同预后患者的上述指标差异,并评估各指标相关性及对预后的预测价值。 结果观察组TAT、PIC、TM、t-PAIC和VASH-1水平均高于对照组(P＜0.05)。两组SF水平差异无统计学意义(P＞0.05)。观察组死亡患者的TAT、PIC、TM、t-PAIC、VASH-1和APACHEⅡ评分均高于存活患者(P＜0.05)。死亡与存活患者间SF水平差异无统计学意义(P＞0.05)。TAT、PIC、TM、t-PAIC和VASH-1与APACHEⅡ评分呈正相关(P＜0.05),SF与APACHEⅡ评分无显著相关性(P＞0.05)。TAT、PIC、TM、t-PAIC和VASH-1预测患者死亡的曲线下面积分别为0.801、0.836、0.886、0.673和0.734(P＜0.05)。 结论血栓四项和VASH-1与AECOPD合并呼吸衰竭患者的病情严重程度及预后相关,对预后评估具有一定价值,而SF与严重程度及预后无显著关联。 |
| 英文摘要: |
| AimTo investigate the levels of four thrombotic markers (thrombin-antithrombin complex (TAT), plasmin-α2 plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue plasminogen activator-inhibitor complex (t-PAIC), vasohibin-1 (VASH-1), and serum ferritin (SF) in patients with AECOPD and respiratory failure, and to examine their correlations with disease severity and prognosis for clinical evaluation. MethodsA total of 80 AECOPD patients with respiratory failure were selected as the observation group, while 80 patients with AECOPD alone were served as the control group. Serum levels of TAT, PIC, TM, t-PAIC, VASH-1, and SF were compared between the two groups. Differences in these indicators among patients with different prognoses in the observation group were analyzed, and the predictive value of each indicator for prognosis was evaluated. ResultsThe levels of TAT, PIC, TM, t-PAIC, and VASH-1 in the observation group were significantly higher than those in the control group (P＜0.05). There was no significant difference in SF between the two groups (P＞0.05). In the observation group, non-survivors had higher TAT, PIC, TM, t-PAIC, VASH-1, and APACHE Ⅱ scores than survivors (P＜0.05). There was no significant difference in SF between non-survivors and survivors (P＞0.05). TAT, PIC, TM, t-PAIC, and VASH-1 were positively correlated with APACHE Ⅱ scores (P＜0.05), while SF showed no significant correlation (P＞0.05). The areas under the ROC curve of TAT, PIC, TM, t-PAIC, and VASH-1 for predicting patient death were 0.801,0.836,0.886,0.673, and 0.734, respectively (P＜0.05). ConclusionThrombus four items and VASH-1 are associated with the severity and prognosis of AECOPD patients with respiratory failure and have certain value in predicting prognosis, while SF shows no significant relationship with severity or prognosis. |
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