| 邹燕,钟黄,叶曼玲.D-二聚体/血小板计数比值对食管胃静脉曲张内镜术后长期再出血风险的预测价值.[J].中南医学科学杂志.,2025,(6):1069-1072. |
| D-二聚体/血小板计数比值对食管胃静脉曲张内镜术后长期再出血风险的预测价值 |
| The predictive value of the D-Dimer/platelet count ratio for long-term rebleeding risk after endoscopic treatment of esophagogastric varices |
| 投稿时间：2025-03-10 修订日期：2025-09-23 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.032 |
| 中文关键词: 食管胃静脉曲张 肝硬化 内镜 DPR 再出血 |
| 英文关键词:esophagogastric varices liver cirrhosis endoscopy DPR rebleeding |
| 基金项目:四川大学自贡市校地科技合作专项(2022CDZG-26)；自贡市重点科技计划项目(2024-YGY-03-15) |
|
| 摘要点击次数: 39 |
| 全文下载次数: 27 |
| 中文摘要: |
| 目的探讨D-二聚体(D-D)/血小板计数(PLT)比值(DPR)对食管胃静脉曲张内镜术后长期再出血风险的预测价值。 方法选取接受食管胃静脉曲张内镜下治疗的肝硬化患者98例,根据随访期间是否再出血分为出血组(n＝25)和未出血组(n＝73)。比较两组临床资料及入院时DPR。采用ROC曲线分析DPR对再出血风险的评估价值。采用Logistic回归分析再出血的影响因素。 结果出血组D-D、DPR高于未出血组,PLT低于未出血组(P＜0.05)。D-D、PLT及DPR对食管胃静脉曲张内镜治疗后再出血具有良好的预测价值,且DPR的AUC高于D-D、PLT(P＜0.05)。出血组门静脉宽度、凝血酶原时间、门静脉血栓比例高于未出血组,纤维蛋白原低于未出血组(P＜0.05)。门静脉血栓、凝血酶原时间、DPR是再出血的危险因素(P＜0.001)。 结论DPR在评估食管胃静脉曲张内镜治疗后长期再出血风险中展现出良好的潜在应用价值。 |
| 英文摘要: |
| AimTo explore the predictive value of the D-Dimer (D-D)/platelet count (PLT) ratio (DPR) for long-term rebleeding risk after endoscopic treatment of esophagogastric varices. MethodsA total of 98 patients with liver cirrhosis who received endoscopic treatment for esophagogastric varices were selected. They were divided into the bleeding group (n＝25) and the non-bleeding group (n＝73) based on whether or not they had rebleeding during the follow-up period. The clinical data and DPR at admission were compared between the two groups. The ROC curve was used to analyze the value of DPR in assessing the risk of rebleeding. Logistic regression was used to analyze the influencing factors of rebleeding. ResultsThe levels of D-D and DPR in the bleeding group were higher than those in the non-bleeding group, while the PLT level was lower (P＜0.05). D-D, PLT, and the DPR all demonstrated significant predictive value for rebleeding following endoscopic treatment of esophagogastric varices, furthermore, the DPR yielded a significantly higher AUC than either D-D or PLT alone (P＜0.05). The portal vein width, prothrombin time and the proportion of portal vein thrombosis in the bleeding group were higher than those in the non-bleeding group, while the fibrinogen level was lower (P＜0.05). Portal vein thrombosis, prothrombin time and DPR are risk factors for rebleeding (P＜0.001). ConclusionDPR shows good potential application value in assessing the risk of rebleeding after endoscopic treatment of esophagogastric varices. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |