| 张洁,陈琳,戴林,张海燕,孟燕,王玉.静脉溶栓联合双重抗血脂对急性缺血性脑卒中伴肥胖患者颈动脉超声及血脂代谢的影响.[J].中南医学科学杂志.,2025,(6):1065-1068. |
| 静脉溶栓联合双重抗血脂对急性缺血性脑卒中伴肥胖患者颈动脉超声及血脂代谢的影响 |
| Effect of intravenous thrombolysis combined with dual anti-lipid treatment on carotid ultrasound and lipid metabolism in obese patients with acute ischemic stroke |
| 投稿时间：2025-02-27 修订日期：2025-08-28 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.031 |
| 中文关键词: 急性缺血性脑卒中 肥胖 静脉溶栓 阿托伐他汀 普罗布考 颈动脉超声 血脂 |
| 英文关键词:acute ischemic stroke obesity intravenous thrombolysis atorvastatin probucol carotid ultrasound blood lipid |
| 基金项目:邢台市重点研发计划自筹项目(2024ZC203) |
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| 中文摘要: |
| 目的观察静脉溶栓联合双重抗血脂对急性缺血性脑卒中伴肥胖患者颈动脉超声及血脂代谢的影响。 方法将本院收治的138例急性缺血性脑卒中伴肥胖患者均分为常规联合组(静脉溶栓联合阿托伐他汀治疗)和双重抗血脂联合组(静脉溶栓联合阿托伐他汀+普罗布考)。比较两组患者治疗前后血脂水平、血清炎症指标[白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]水平和颈动脉超声参数[颈动脉内膜中膜厚度(IMT)、收缩期峰值流速(PSV)、舒张期末流速(EDV)]、美国国立卫生研究院卒中量表(NIHSS)及日常生活能力量表(ADL)评分,以及不良反应发生情况。 结果治疗后,两组血脂总胆固醇、甘油三酯、低密度脂蛋白胆固醇、氧化型低密度脂蛋白、血清IL-6、hs-CRP水平和IMT、EDV以及NIHSS评分均降低(P＜0.05),且双重抗血脂联合组低于常规联合组(P＜0.05)；两组高密度脂蛋白胆固醇、PSV以及ADL评分均升高(P＜0.05),且双重抗血脂联合组PSV和ADL评分高于常规联合组(P＜0.05)。两组不良反应比较,差异无显著性(P＞0.05)。 结论静脉溶栓联合双重抗血脂能显著改善急性缺血性脑卒中伴肥胖患者颈动脉超声参数、血脂代谢。 |
| 英文摘要: |
| AimTo observe the effects of intravenous thrombolysis combined with dual anti-lipid on carotid ultrasound and lipid metabolism in obese patients with acute ischemic stroke. MethodsA total of 138 obese patients with acute ischemic stroke admitted to our hospital were divided into a conventional combination group (treated with intravenous thrombolysis and atorvastatin) and a dual anti-lipid combination group (treated with intravenous thrombolysis and atorvastatin+probucol). The levels of blood lipid, serum inflammatory indexes [interleukin-6 (IL-6), high-sensitivity C reactive protein (hs-CRP)], carotid ultrasound parameters [intima-media thickness (IMT), peak systolic velocity (PSV), end-diastolic velocity (EDV) ], national institute of health stroke scale (NIHSS), activities of daily living (ADL) and adverse reactions were compared between the two groups before and after treatment. ResultsAfter treatment, the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, oxidized low-density lipoprotein, serum IL-6, hs-CRP, as well as IMT, EDV, and NIHSS scores in both groups were decreased (P＜0.05), and the dual anti-lipid combination group was lower than the conventional combination group (P＜0.05); Both groups showed an increase in high-density lipoprotein cholesterol, PSV, and ADL scores (P＜0.05), and the PSV and ADL scores in the dual anti-lipid combination group were higher than those in the conventional combination group (P＜0.05). There was no significant difference in adverse reactions between the two groups (P＞0.05). ConclusionThe combination of intravenous thrombolysis and dual anti-lipid therapy can significantly improve the carotid ultrasound parameters and lipid metabolism in obese patients with acute ischemic stroke. |
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