| 胡云丽,刘杰,郭莉,赵曙光.膈肌超声联合血清胆碱酯酶活性对急性有机磷农药中毒呼吸衰竭患者撤机结局的预测价值.[J].中南医学科学杂志.,2025,(6):1053-1056. |
| 膈肌超声联合血清胆碱酯酶活性对急性有机磷农药中毒呼吸衰竭患者撤机结局的预测价值 |
| The predictive value of diaphragmatic ultrasound combined with serum cholinesterase activity for the weaning outcomes of patients with acute organophosphate pesticide poisoning respiratory failure |
| 投稿时间：2025-01-21 修订日期：2025-08-28 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.028 |
| 中文关键词: 急性有机磷农药中毒 呼吸衰竭 膈肌超声 胆碱酯酶 撤机结局 |
| 英文关键词:AOPP respiratory failure diaphragmatic ultrasound ChE weaning outcome |
| 基金项目:皖南医学院校级科研项目(LC202202) |
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| 中文摘要: |
| 目的探讨膈肌超声联合血清胆碱酯酶活性对急性有机磷农药中毒(AOPP)呼吸衰竭患者撤机结局的预测价值。 方法选取本院收治的经治疗计划撤机的AOPP呼吸衰竭患者57例作为研究对象,根据撤机结局将其分为撤机成功组35例和撤机失败组22例。比较两组膈肌移动度(DE)、膈肌增厚分数(DTF)和血清胆碱酯酶(ChE)活性。采用Logistic分析撤机结局的影响因素,利用ROC曲线评价DE、DTF、ChE活性及三者联合对撤机结局的预测价值。 结果撤机失败组平均动脉压、心率、呼吸频次高于撤机成功组(P＜0.05),DE、DTF和ChE活性均低于撤机成功组(P＜0.05)。Logistic分析结果显示,DE、DTF及ChE活性是撤机结局的影响因素(P＜0.05)。ROC分析结果显示,DE、DTF、ChE联合预测的AUC、特异度均显著高于其单独预测值(P＜0.05)。 结论DE、DTF联合ChE活性对AOPP呼吸衰竭患者的撤机结局具有较好的预测价值。 |
| 英文摘要: |
| AimTo explore the predictive value of diaphragmatic ultrasound combined with serum cholinesterase activity for the weaning outcomes of patients with acute organophosphate pesticide poisoning (AOPP) respiratory failure. MethodsA total of 57 patients with AOPP respiratory failure who were treated and scheduled for weaning in our hospital were selected as the research subjects. According to the weaning outcomes, the patients were divided into a successful weaning group of 35 cases and a failed weaning group of 22 cases. The diaphragmatic excursion (DE), diaphragmatic thickening fraction (DTF), and serum cholinesterase (ChE) activity were compared between the two groups. Logistic analysis was used to identify the influencing factors of weaning outcomes, and ROC curves were used to evaluate the predictive value of DE, DTF, and ChE activity, as well as their combined predictive value on patient weaning outcomes. ResultsThe average arterial pressure, heart rate, and respiratory frequency of the failed weaning group were higher than those of the successful weaning group (P＜0.05), while the DE, DTF, and ChE activities were lower than those of the successful weaning group (P＜0.05). The Logistic analysis results showed that DE, DTF, and ChE activity were factors affecting the weaning outcomes (P＜0.05). The ROC analysis results showed that the AUC and specificity of the combined prediction of DE, DTF, and ChE were significantly higher than their individual prediction values (P＜0.05). ConclusionThe combination of DE, DTF, and ChE activity has good predictive value for the weaning outcome of AOPP respiratory failure patients. |
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