| 李艳,刘翠,李清智.安徽地区儿童维生素K水平与骨骼生长、神经发育的相关性.[J].中南医学科学杂志.,2025,(6):1037-1040. |
| 安徽地区儿童维生素K水平与骨骼生长、神经发育的相关性 |
| Correlation between vitamin K levels and bone growth and neurodevelopment in children from Anhui region |
| 投稿时间：2024-11-28 修订日期：2025-05-30 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.024 |
| 中文关键词: 儿童 维生素K 骨代谢 神经发育 安徽地区 |
| 英文关键词:children vitamin K bone metabolism neurodevelopment Anhui region |
| 基金项目:安徽省卫生健康委科研项目(AHwJ2021a025) |
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| 中文摘要: |
| 目的探究安徽地区儿童维生素K水平与骨骼生长、神经发育的相关性。 方法回顾性选择进行体检的儿童2 687例,根据骨骼生长及神经发育情况分为骨骼发育正常组(n＝2 231)与骨骼发育异常组(n＝456)；分为神经发育正常组(n＝2 534)与神经发育异常组(n＝153)。记录各组血清维生素K1、K2水平、骨代谢指标[钙、磷、碱性磷酸酶(ALP)、甲状旁腺激素、I型胶原C-末端肽交联、I型胶原羧基端末肽)],并采用Griffiths儿童神经发育评估量表评估神经发育情况。分析维生素K水平与骨代谢指标及Griffiths量表评分的相关性。 结果骨骼发育异常组维生素K1、K2、钙、磷水平低于骨骼发育正常组,ALP水平高于骨骼发育正常组(P＜0.05)。维生素K1、K2与钙、磷水平呈正相关,与ALP水平呈负相关(P＜0.05)。神经发育异常组维生素K1、K2水平、Griffiths量表各维度评分及总分均低于神经发育正常组(P＜0.05)。维生素K1、K2与Griffiths量表评分呈正相关(P＜0.05)。 结论安徽地区儿童维生素K水平与骨骼生长和神经发育显著相关,维生素K水平较低者骨骼发育异常和神经发育异常风险较高,且维生素K水平与骨代谢指标及神经发育评估得分呈正相关。 |
| 英文摘要: |
| AimTo investigate the correlation between vitamin K levels and bone growth and neurodevelopment in children from Anhui region. MethodsA total of 2 687 children undergoing physical examination were retrospectively selected. The children were divided into a bone development normal group (n＝2 231) and a bone development abnormal group (n＝456), or a neurodevelopment normal group (n＝2 534) and a neurodevelopment abnormal group (n＝153) based on growth assessment. Serum vitamin K1 and K2 levels, bone metabolism indicators [calcium, phosphorus, alkaline phosphatase (ALP), parathyroid hormone, type I collagen C-terminal telopeptide, type I collagen carboxy-terminal telopeptide)] were recorded. Neurodevelopment was assessed using the Griffiths Mental Development Scales. The correlation between vitamin K levels and bone metabolism indicators and Griffiths scale scores was analyzed. ResultsVitamin K1 and K2, calcium and phosphorus levels in the bone development abnormal group were lower, while ALP level was higher than those in the normal group (P＜0.05). Vitamin K1 and K2 levels were positively correlated with calcium and phosphorus levels, bbut negatively correlated with ALP level (P＜0.05). Vitamin K1 and K2 levels, all domain scores and the total score of the Griffiths scale in the neurodevelopment abnormal group were lower than those in the normal group (P＜0.05). Vitamin K1 and K2 levels were positively correlated with the Griffiths scale scores (P＜0.05). ConclusionVitamin K levels are significantly correlated with bone growth and neurodevelopment in children from Anhui region. Lower vitamin K levels are associated with higher risks of bone development and neurodevelopment abnormalities, and vitamin K levels are positively correlated with bone metabolism indicators and neurodevelopment assessment scores. |
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