| 黄宏来,彭程,李清智.蓝芩口服液联合头孢克肟治疗小儿急性上呼吸道感染的疗效分析.[J].中南医学科学杂志.,2025,(6):1027-1030. |
| 蓝芩口服液联合头孢克肟治疗小儿急性上呼吸道感染的疗效分析 |
| Efficacy of Lanqin oral liquid combined with cefixime in treating acute upper respiratory tract infection in children |
| 投稿时间：2024-08-09 修订日期：2025-02-26 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.021 |
| 中文关键词: 蓝芩口服液 头孢克肟 急性上呼吸道感染 疗效 小儿 |
| 英文关键词:Lanqin oral liquid cefixime acute upper respiratory tract infection efficacy children |
| 基金项目:安徽省卫生健康委科研项目立项项目(AHwJ2021a029) |
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| 中文摘要: |
| 目的探讨蓝芩口服液联合头孢克肟治疗小儿急性上呼吸道感染的疗效。 方法将258例急性上呼吸道感染的儿童随机分为对照组和观察组,每组各129例。两组均采取常规治疗,对照组采用头孢克肟治疗,观察组在对照组的基础上加用蓝芩口服液。观察两组患儿的临床疗效、主要症状消退时间、炎症因子和免疫功能水平以及不良反应发生情况。 结果治疗后,观察组的总有效率高于对照组(P＜0.05)；观察组发热、咽痛、鼻塞、咳嗽等症状的消退时间短于对照组(P＜0.05)；观察组白细胞介素(IL)-2、IL-6、C反应蛋白低于对照组(P＜0.05)；观察组免疫指标CD4＋、CD4＋/CD8＋高于对照组(P＜0.05)；CD8＋低于对照组(P＜0.05)。两组不良反应发生率差异无统计学意义(P＞0.05)。 结论蓝芩口服液联合头孢克肟能有效提高小儿急性上呼吸道感染的治疗效果,缩短整体治疗时间,且能有效改善免疫功能,降低炎症反应,同时药物安全性高。 |
| 英文摘要: |
| AimTo investigate the efficacy of Lanqin oral liquid combined with cefixime in treating acute upper respiratory tract infection in children. MethodsA total of 258 children with acute upper respiratory tract infection were randomly divided into a control group and an observation group, with 129 cases in each group. Both groups received conventional treatment. The control group was additionally treated with cefixime, while the observation group received Lanqin oral liquid combined with cefixime based on the control group. Clinical efficacy, main symptom resolution time, inflammatory factors, immune function indicators, and adverse reactions were compared between the two groups. ResultsThe total effective rate was higher in the observation group than in the control group (P＜0.05). The resolution time of fever, sore throat, nasal congestion, and cough in the observation group was shorter than those in the control group (P＜0.05). The levels of interleukin (IL)-2, IL-6, and C-reactive protein in the observation group were lower than those in the control group (P＜0.05). The observation group showed higher CD4＋ and CD4＋/CD8＋ ratios and lower CD8＋ levels compared with the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). ConclusionLanqin oral liquid combined with cefixime can effectively improve clinical efficacy, shorten symptom duration, enhance immune function, reduce inflammatory response, and exhibits good safety in children with acute upper respiratory tract infection. |
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