| 夏洁,陈凡,蒋飞,潘善刚,陈蓓,吴华蓉,汪永.2型糖尿病合并白内障术后黄斑水肿的危险因素分析及预测模型构建.[J].中南医学科学杂志.,2025,(6):1023-1026. |
| 2型糖尿病合并白内障术后黄斑水肿的危险因素分析及预测模型构建 |
| Analysis of risk factors and construction of a prediction model for macular edema after cataract surgery in type 2 diabetes mellitus patients |
| 投稿时间：2024-10-23 修订日期：2025-03-18 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.020 |
| 中文关键词: 2型糖尿病 白内障 黄斑水肿 危险因素 预测模型 |
| 英文关键词:type 2 diabetes mellitus cataract macular edema risk factors prediction model |
| 基金项目:安徽省第六批卫生健康适宜技术推广项目(SYJS202105) |
| 作者 | 单位 | E-mail | | 夏洁 | 安徽医科大学,安徽合肥230032
庐江县人民医院眼科,安徽合肥231500 | e-mail为13675654327@163.com,e-mail为18690623805@163.com | | 陈凡 | 安庆市立医院眼科,安徽安庆246000 | | | 蒋飞 | 安庆市立医院眼科,安徽安庆246000 | | | 潘善刚 | 安庆市立医院眼科,安徽安庆246000 | | | 陈蓓 | 安庆市立医院眼科,安徽安庆246000 | | | 吴华蓉 | 安庆市立医院眼科,安徽安庆246000 | | | 汪永 | 安徽医科大学第一附属医院眼科,安徽合肥230022 | e-mail为13675654327@163.com,e-mail为18690623805@163.com |
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| 中文摘要: |
| 目的分析2型糖尿病(T2DM)合并白内障患者术后黄斑水肿(ME)危险因素,并构建预测模型。 方法选取T2DM合并白内障患者98例,均行超声乳化人工晶状体植入术,根据术后ME情况分为ME组(47例)和无ME组(51例)。比较两组临床资料,采用Logistic回归分析术后发生ME的危险因素并构建其预测模型,通过ROC曲线评估危险因素及构建模型的预测效能。 结果ME组视网膜病变占比、房水成纤维细胞生长因子(FGF)、单核细胞趋化因子-1(MCP-1)、转化生长因子-β2(TGF-β2)水平高于无ME组(P＜0.05)。视网膜病变(X1)、房水FGF(X2)、MCP-1(X3)、TGF-β2(X4)升高是术后发生ME的独立危险因素(P＜0.05),构建的预测模型为Logit(P)=4.216+0.392X1+1.406X2+1.263X3+2.148X4。ROC分析显示模型预测术后发生ME的AUC为0.962(95%CI:0.929～0.995),灵敏度为95.70%,特异度为84.32%。 结论视网膜病变及房水FGF、MCP-1、TGF-β2升高是T2DM合并白内障患者术后发生ME的危险因素,据此构建的预测模型具有良好预测效能。 |
| 英文摘要: |
| AimTo analyze risk factors for macular edema (ME) after cataract surgery in type 2 diabetes mellitus (T2DM) patients and construct a prediction model. MethodsNinety-eight T2DM patients with cataract who underwent phacoemulsification with intraocular lens implantation were divided into an ME group (47 cases) and a non-ME group (51 cases) according to postoperative ME occurrence. Clinical data were compared between the two groups. Logistic regression was used to identify risk factors and construct a prediction model. ROC curve was used to evaluate the predictive efficacy. ResultsThe ME group had significantly higher proportions of retinopathy and higher aqueous levels of fibroblast growth factor (FGF), monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-β2 (TGF-β2) compared with the non-ME group (P＜0.05). Retinopathy (X1) and elevated aqueous FGF (X2), MCP-1 (X3), and TGF-β2 (X4) were independent risk factors for postoperative ME (P＜0.05). The prediction model was constructed according to the formula Logit(P)=4.216+0.392X1+1.406X2+1.263X3+2.148X4. ROC analysis showed that the model had an AUC of 0.962 (95%CI:0.929－0.995) with 95.70% sensitivity and 84.32% specificity, respectively. ConclusionRetinopathy and elevated aqueous FGF, MCP-1, and TGF-β2 are risk factors for postoperative ME in T2DM patients with cataract, and the constructed prediction model shows good predictive performance. |
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