| 杨风刚,唐宇,姚红为,梁博娜,鲁国,吕凤华.脑梗死患者外周血Hcy、Lp-PLA2、sdLDLC/LDLC比值与早期神经功能恶化的关系.[J].中南医学科学杂志.,2025,(6):1015-1018. |
| 脑梗死患者外周血Hcy、Lp-PLA2、sdLDLC/LDLC比值与早期神经功能恶化的关系 |
| Association of peripheral blood Hcy, Lp-PLA2, and sdLDLC/LDLC ratio with early neurological deterioration in patients with cerebral infarction |
| 投稿时间：2025-04-01 修订日期：2025-10-08 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.018 |
| 中文关键词: 脑梗死 Hcy Lp-PLA2 sdLDLC/LDLC 早期神经功能恶化 |
| 英文关键词:cerebral infarction Hcy Lp-PLA2 sdLDLC/LDLC early neurological deterioration |
| 基金项目:山东省医药卫生科技发展计划项目(2017WS537) |
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| 中文摘要: |
| 目的探讨脑梗死(CI)患者外周血同型半胱氨酸(Hcy)、脂蛋白相关磷脂酶A2(Lp-PLA2)、小而密低密度脂蛋白胆固醇(sdLDLC)/LDLC比值与早期神经功能恶化(END)的关系。 方法选取120例CI患者(CI组),根据是否发生END分为END组50例和非END组70例；END组根据神经功能缺损程度分为轻度组20例、中度组16例、重度组14例。另选取同期体检健康者140例(健康组)。比较各组外周血Hcy、Lp-PLA2、sdLDLC/LDLC比值、美国国立卫生研究院卒中量表(NIHSS)评分、Alberta卒中早期CT评分(ASPECTS)水平。采用多因素Logistic回归分析各指标与END发生的关系。 结果CI组血清Hcy、Lp-PLA2、sdLDLC/LDLC比值高于健康组(P＜0.05)。END组Hcy、Lp-PLA2、sdLDLC/LDLC、NIHSS评分高于非END组,ASPECTS评分低于非END组(P＜0.05)。END患者Hcy、Lp-PLA2、sdLDLC/LDLC、NIHSS评分轻度组＜中度组＜重度组,ASPECTS评分轻度组＞中度组＞重度组(P＜0.05)。Hcy、Lp-PLA2、sdLDLC/LDLC是CI患者发生END的独立危险因素(P＜0.05)。 结论CI患者外周血Hcy、Lp-PLA2、sdLDLC/LDLC是CI患者发生END的独立危险因素,三者的检测对END的早期预警具有潜在临床价值。 |
| 英文摘要: |
| AimTo investigate the relationship between peripheral blood homocysteine (Hcy), lipoprotein-associated phospholipase A2 (Lp-PLA2), small dense low-density lipoprotein cholesterol (sdLDLC)/LDLC ratio and early neurological deterioration (END) in patients with cerebral infarction (CI). MethodsA total of 120 CI patients (CI group) were selected and divided into an END group (50 cases) and a non-END group (70 cases) based on the occurrence of END; The END group were further stratified by severity into mild (20 cases), moderate (16 cases), and severe (14 cases) groups. Another 140 healthy individuals during the same period served as the healthy control group. Peripheral blood Hcy, Lp-PLA2, sdLDLC/LDLC ratio, national institutes of health stroke scale (NIHSS) score, and Alberta stroke program early CT score (ASPECTS) were compared among the groups. Multivariate Logistic regression analysis was used to analyze the relationship between each indicator and the occurrence of END. ResultsSerum Hcy, Lp-PLA2, and sdLDLC/LDLC ratio in the CI group were higher than those in the healthy group (P＜0.05). The END group had higher levels of Hcy, Lp-PLA2, sdLDLC/LDLC ratio, and NIHSS scores, and lower ASPECTS scores than the non-END group (P＜0.05). Among END patients, Hcy, Lp-PLA2, sdLDLC/LDLC ratio, and NIHSS scores increased with severity (mild＜moderate＜severe), while ASPECTS scores decreased (mild＞moderate＞severe) (P＜0.05). Hcy, Lp-PLA2, and sdLDLC/LDLC ratio were identified as independent risk factors for END in CI patients (P＜0.05). ConclusionPeripheral blood Hcy, Lp-PLA2, and sdLDLC/LDLC ratio are independent risk factors for END in CI patients, and their detection has potential clinical value for the early warning of END. |
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