| 任义财,周利平,陈馨,何林,张利波.MRI评估前列腺周围脂肪组织厚度对前列腺癌发生去势抵抗的预测价值.[J].中南医学科学杂志.,2025,(6):1003-1006. |
| MRI评估前列腺周围脂肪组织厚度对前列腺癌发生去势抵抗的预测价值 |
| The predictive value of MRI evaluation of prostatic perifat thickness for castration resistance in prostate carcinoma |
| 投稿时间：2025-01-29 修订日期：2025-09-28 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.015 |
| 中文关键词: 磁共振成像 前列腺周围脂肪组织厚度 前列腺癌 去势抵抗性前列腺癌 |
| 英文关键词:MRI PPFT PCa CRPC |
| 基金项目:四川省中医药管理局科研专项项目(2020LC0174) |
|
| 摘要点击次数: 84 |
| 全文下载次数: 37 |
| 中文摘要: |
| 目的探讨磁共振成像(MRI)评估前列腺周围脂肪组织厚度(PPFT)对前列腺癌(PCa)发生去势抵抗的预测价值。 方法选取本院收治的接受雄激素剥夺疗法的80例PCa患者。根据是否发生去势抵抗性前列腺癌(CRPC)将其分为CRPC组和非CRPC组。比较两组患者临床资料及PPFT。采用Kaplan Meier生存曲线分析CRPC发生情况,采用多因素Logistic回归分析PCa发生CRPC的影响因素,采用ROC曲线分析PPFT对PCa发生去势抵抗的预测价值。 结果CRPC组和非CRPC组患者Gleason评分、美国东部肿瘤协作组(ECOG)评分、初始前列腺特异抗原(PSA)水平、PSA最低值(PSA nadir)以及PPFT比较,差异均有统计学意义(P＜0.05)。Gleason评分、ECOG评分、PSA nadir、PPFT是PCa发生CRPC的影响因素(P＜0.05)。PPFT预测PCa发生CRPC的AUC为0.880(P＜0.001),最佳截断值为0.72 cm,此时灵敏度为92.86%,特异度为75.00%。 结论MRI评估PPFT对PCa发生CRPC具有良好的预测价值。 |
| 英文摘要: |
| AimTo explore the predictive value of magnetic resonance imaging (MRI) evaluation of prostatic perifat thickness (PPFT) for castration resistance in prostate carcinoma (PCa). MethodsA total of 80 patients with PCa treated with androgen deprivation therapy in our hospital were selected. According to the occurrence of castration-resistant prostate cancer (CRPC), they were divided into the CRPC group and the non-CRPC group. The clinical data and PPFT were compared between the two groups. Kaplan Meier survival curve was used to analyze the occurrence of CRPC. Multivariate Logistic regression was used to analyze the influencing factors of CRPC in PCa. ROC curve was used to analyze the predictive value of PPFT for castration resistance in PCa. ResultsThere were significant differences in Gleason score, eastern cooperative oncology group (ECOG) score, initial prostate-specific antigen (PSA) level, PSA nadir and PPFT between CRPC group and non-CRPC group (P＜0.05). Gleason score, ECOG score, PSA nadir and PPFT were influencing factors for CRPC in PCa (P＜0.05). The AUC of PPFT in predicting CRPC in PCa was 0.880 (P＜0.001). The optimal cut-off value was 0.72 cm, with a sensitivity of 92.86% and a specificity of 75.00%. ConclusionMRI evaluation of PPFT has a good predictive value for CRPC in PCa. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|