| 高剑,郑晓慧,王娅,巩凡,马国续.糖尿病足溃疡患者创面Yap、TAZ蛋白表达的临床意义.[J].中南医学科学杂志.,2025,(6):991-994. |
| 糖尿病足溃疡患者创面Yap、TAZ蛋白表达的临床意义 |
| Clinical significance of Yap and TAZ protein expression in wounds of diabetic foot ulcer patients |
| 投稿时间：2025-04-10 修订日期：2025-07-18 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.012 |
| 中文关键词: 糖尿病足溃疡 创面 Yap蛋白 TAZ蛋白 |
| 英文关键词:diabetic foot ulcer wound Yap protein TAZ protein |
| 基金项目:宁夏自然科学基金项目课题(2024AAC03527)；银川市科技创新项目(2024SF005) |
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| 中文摘要: |
| 目的研究糖尿病足溃疡(DFU)患者创面Yes-相关蛋白(Yap)、转录共刺激因子(TAZ)蛋白表达的临床意义。 方法选取DFU患者303例,根据其预后情况分为预后良好组215例和预后不良组88例；根据病变程度分为轻度组110例、中度组148例和重度组45例。比较各组临床资料及Yap、TAZ蛋白表达水平。采用Spearman相关性分析Yap、TAZ与病变程度的相关性；采用多因素Logistic回归方程分析影响因素,采用ROC曲线分析Yap、TAZ对预后的影响。 结果Yap、TAZ蛋白阳性表达率轻度组＞中度组＞重度组(P＜0.05)。DFU患者Yap、TAZ蛋白阳性表达与病变程度呈负相关(P＜0.001)。预后不良组年龄、重度DFU比例、DFU病程、空腹血糖(FBG)、C反应蛋白(CRP)、降钙素原均较预后良好组高,Yap和TAZ蛋白阳性表达率及水凝胶清创比例均较预后良好组低(P＜0.05)。年龄、DFU病变程度、FBG、CRP均为预后的危险因素,Yap、TAZ蛋白表达及水凝胶清创为预后的保护因素(P＜0.05)。Yap、TAZ蛋白表达对预后均具有一定预测价值(P＜0.05)。 结论DFU患者Yap、TAZ蛋白高表达与病变程度呈负相关,Yap、TAZ蛋白表达对DFU患者预后均具有一定预测价值。 |
| 英文摘要: |
| AimTo investigate the clinical significance of Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (TAZ) protein expression in wounds of diabetic foot ulcer (DFU) patients. MethodsA total of 303 DFU patients were enrolled. Based on prognosis outcomes, they were divided into a good prognosis group (n＝215) and a poor prognosis group (n＝88). Based on lesion severity, they were divided into mild (n＝110), moderate (n＝148), and severe (n＝45) groups. Clinical data and Yap/TAZ protein expression levels were compared among groups. Spearman correlation analysis was used to assess the correlation between Yap/TAZ expression and lesion severity. Multivariate Logistic regression was employed to analyze the influencing factors, and ROC analysis was used to evaluate the impact of Yap/TAZ expression on prognosis. ResultsThe positive expression rates of Yap and TAZ proteins were in an order of the mild group > the moderate group > the severe group (P＜0.05). In DFU patients, the positive expression of Yap and TAZ proteins was negatively correlated with the severity of the lesions (P＜0.001). Compared with the good prognosis group, the poor prognosis group had higher age, a higher proportion of severe DFU, longer DFU duration, higher fasting blood glucose (FBG), C-reactive protein (CRP), procalcitonin levels, while the positive expression rates of Yap and TAZ proteins and the proportion of hydrogel debridement were lower (P＜0.05). Age, DFU severity, FBG, and CRP were risk factors for prognosis, whereas Yap and TAZ protein expression and hydrogel debridement were protective factors (P＜0.05). The expression of Yap and TAZ proteins had certain predictive value for prognosis (P＜0.05). ConclusionHigh expression of Yap and TAZ proteins in DFU patients is inversely correlated with lesion severity. Both Yap and TAZ protein expression demonstrate predictive value for the prognosis of DFU patients. |
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