| 陈晶,白宁,白勇,叶斯波力·塔斯恒,周高晋,夏依木拉提·迪力木拉提.miR-222、miR-30b与PHPT患者骨代谢指标及术后复发的关系.[J].中南医学科学杂志.,2025,(6):987-990, 1124. |
| miR-222、miR-30b与PHPT患者骨代谢指标及术后复发的关系 |
| The relationship between miR-222, miR-30b and bone metabolism indicators and postoperative recurrence in patients with PHPT |
| 投稿时间：2025-04-16 修订日期：2025-08-19 |
| DOI：10.15972/j.cnki.43-1509/r.2025.06.011 |
| 中文关键词: 原发性甲状旁腺功能亢进 miR-222 miR-30b 骨代谢 术后复发 |
| 英文关键词:PHPT miR-222 miR-30b bone metabolism postoperative recurren |
| 基金项目:新疆维吾尔自治区自然科学基金项目(2022D01C267) |
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| 中文摘要: |
| 目的分析血清微小RNA(miR)-222、miR-30b与原发性甲状旁腺功能亢进(PHPT)患者骨代谢指标及术后复发的关系。 方法选择130例PHPT患者作为PHPT组,选择同期入院健康体检者80例作为对照组。比较两组甲状旁腺功能、骨代谢指标及血清miR-222、miR-30b水平。所有患者术后随访1.5年观察复发情况,比较未复发者和复发者的临床指标差异。采用Logistic回归分析PHPT患者术后复发的影响因素；采用ROC曲线分析miR-222、miR-30b对PHPT患者术后复发的预测价值。 结果PHPT组血清血磷、25-羟维生素D3[25(OH)D3]、miR-30b水平低于对照组(P＜0.05),血清甲状旁腺激素(PTH)、血钙、miR-222及骨代谢指标水平高于对照组(P＜0.05)。血清miR-222与血钙、PTH、骨代谢指标呈正相关,与血磷、25(OH)D3呈负相关(P＜0.05)；而miR-30b与上述指标相关性相反(P＜0.05)。PHPT患者术后复发57例(43.85%)。复发患者血清血磷、25(OH)D3、miR-30b低于未复发者(P＜0.05),血清PTH、血钙、miR-222及骨代谢指标高于未复发者(P＜0.05)。高水平PTH、血钙、miR-222与低水平血磷、25(OH)D3、miR-30b为PHPT患者术后复发的独立危险因素(P＜0.05)。miR-222对PHPT患者术后复发预测的AUC为0.906,miR-30b为0.925。 结论PHPT患者的血清miR-222、miR-30b表达水平与骨代谢指标具有相关性,对PHPT术后复发具有较高预测效能。 |
| 英文摘要: |
| AimTo analyze the relationship between the serum microRNA (miR)-222, miR-30b and bone metabolism indicators, and postoperative recurrence in patients with primary hyperparathyroidism (PHPT). MethodsTotally 130 PHPT patients were selected as the PHPT group, and 80 healthy examinees admitted during the same period were selected as the control group. The parathyroid function, bone metabolism indicators, and serum miR-222 and miR-30b levels between two groups were compared. All patients were followed up for 1.5 years after surgery to observe the recurrence situation, and the differences in clinical indicators between non-recurrent and recurrent patients were compared. Logistic regression was used to analyze the influencing factors of postoperative recurrence in PHPT patients; ROC curve analysis was used to evaluate the predictive value of miR-222 and miR-30b for postoperative recurrence in PHPT patients. ResultsThe levels of serum phosphorus, 25 dihydroxyvitamin D3 [25 (OH) D3], and miR-30b in the PHPT group were lower than those in the control group (P＜0.05), while the levels of serum parathyroid hormone (PTH), blood calcium, miR-222 and bone metabolism indicators were higher than those in the control group (P＜0.05). Serum miR-222 is positively correlated with blood calcium, PTH, bone metabolism indicators, but negatively correlated with blood phosphorus and 25(OH)D3 (P＜0.05); The correlation between miR-30b and the above indicators was opposite (P＜0.05). Totally 57 cases (43.85%) of PHPT patients experienced postoperative recurrence. The serum phosphorus, 25 (OH) D3, and miR-30b levels in recurrent patients were lower than those in non-recurrent patients (P＜0.05), while serum PTH, blood calcium, miR-222, bone metabolism indicators levels were higher than those in non-recurrent patients (P＜0.05). High levels of PTH, blood calcium and miR-222, as well as low levels of blood phosphorus, 25(OH)D3, and miR-30b, were independent risk factors for postoperative recurrence in PHPT patients (P＜0.05). The AUC of miR-222 for predicting postoperative recurrence in PHPT patients is 0.906, and the AUC of miR-30b was 0.925. ConclusionThe expression levels of serum miR-222 and miR-30b in PHPT patients are correlated with bone metabolism indicators, and have a high predictive power for postoperative recurrence of PHPT. |
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