| 赵景琳,王睿,魏琦,郭胜超,代庆春.泛免疫炎症值与脓毒症并发ARDS患者疾病转归的关系.[J].中南医学科学杂志.,2025,(2):264-266, 299. |
| 泛免疫炎症值与脓毒症并发ARDS患者疾病转归的关系 |
| Correlation between pan-immune inflammation value and disease outcomes in patients with sepsis complicated by ARDS |
| 投稿时间：2024-06-07 修订日期：2025-01-08 |
| DOI：10.15972/j.cnki.43-1509/r.2025.02.017 |
| 中文关键词: 脓毒症 急性呼吸窘迫综合征 泛免疫炎症值 疾病转归 [ |
| 英文关键词:sepsis acute respiratory distress syndrome pan-immune inflammatory value disease outcome |
| 基金项目:河北省医学科学研究课题计划资助(20251512) |
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| 中文摘要: |
| 目的探讨泛免疫炎症值(PIV)与脓毒症并发急性呼吸窘迫综合征(ARDS)患者疾病转归的关系。 方法选取132例脓毒症并发ARDS患者,根据氧合指数(OI)分为轻度组(n＝47)、中度组(n＝51)和重度组(n＝34),检测并计算PIV。根据28天疾病转归分为死亡组(n＝43)和生存组(n＝89)。采用受试者操作特征曲线分析PIV对疾病转归的评估价值,并通过多因素Logistic回归分析其影响因素。 结果死亡组机械通气时间≥3天比例、器官衰竭个数≥2个比例高于生存组；PIV水平轻度组＜中度组＜重度组,生存组＜死亡组；OI水平重度组＜中度组＜轻度组,死亡组＜生存组(P＜0.05)。PIV与OI呈负相关(P＜0.05)。多因素Logistic回归分析发现,机械通气时间≥3天、脏器衰竭个数≥2个、PIV高表达是疾病转归的影响因素(P＜0.05)；PIV对脓毒症并发ARDS患者疾病转归具有良好的评估价值(P＜0.001)。 结论高PIV值与脓毒症并发ARDS患者病情严重程度密切相关,可能是一种评估预后的新型血液学指标。 |
| 英文摘要: |
| AimTo investigate the correlation between pan-immune inflammatory value (PIV) and disease outcomes in patients with sepsis complicated by acute respiratory distress syndrome (ARDS). MethodsA total of 132 patients with sepsis complicated by ARDS were selected and divided into mild group (n＝47), moderate group (n＝51) and severe group (n＝34), according to oxygenation index (OI). PIV was detected and calculated. According to the 28-day disease outcomes, they were divided into death group (n＝43) and survival group (n＝89). The evaluation value of PIV on disease outcomes was analyzed by subject operation characteristic curve, and the influencing factors were analyzed by multivariate Logistic regression. ResultsThe proportion of mechanical ventilation time ≥3 days and the number of organ failure ≥2 in the death group were higher than those in the survival group. PIV level was in an order of mild group＜moderate group＜severe group, and survival group＜death group. OI level was in an order of severe group＜moderate group＜mild group, and death group＜survival gropu (P＜0.05). PIV was negatively correlated with OI, OI level (P＜0.05). Multivariate Logistic regression analysis showed that mechanical ventilation duration ≥3 days, number of organ failure ≥2, high expression of PIV were the influencing factors of disease outcomes (P＜0.05). PIV has a good value in evaluating the disease outcomes of patients with sepsis complicated by ARDS (P＜0.001). ConclusionHigh PIV is closely related to the severity of ARDS patients with sepsis, and may be a new hematological index to evaluate the prognosis. |
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