| 杨婉晨,符俊达,朱海萍,贾娜,孙轶军.低浓度阿托品对LIM豚鼠屈光度、眼轴及巩膜氧化应激的影响.[J].中南医学科学杂志.,2025,(2):232-235. |
| 低浓度阿托品对LIM豚鼠屈光度、眼轴及巩膜氧化应激的影响 |
| Effects of low-concentration of atropine on refraction, axial length, and scleral oxidative stress in lens-induced myopia guinea pigs |
| 投稿时间：2024-01-05 修订日期：2025-01-10 |
| DOI：10.15972/j.cnki.43-1509/r.2025.02.009 |
| 中文关键词: 低浓度阿托品 LIM 眼轴长度 巩膜组织形态 氧化应激 豚鼠 [ |
| 英文关键词:low-concentration atropine LIM axial length scleral morphology oxidative stress guinea pig |
| 基金项目:秦皇岛市科学技术研究与发展计划项目(202301A190) |
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| 中文摘要: |
| 目的探讨低浓度阿托品(ATR)对光学离焦性近视(LIM)豚鼠屈光度、眼轴及巩膜氧化应激的影响。 方法选择造模成功的LIM豚鼠30只,其中右眼为实验眼,左眼为对照眼,将大鼠随机均分为对照组(右眼0.3%玻璃酸钠滴眼1次/天)、ATR1组(右眼ATR滴眼1次/天)和ATR2组(右眼ATR滴眼2次/天)。比较各组屈光度、眼轴长度、巩膜病理形态、超氧化物歧化酶(SOD)和丙二醛(MDA)含量。 结果与实验前比较,实验后各组左眼屈光度、SOD降低,眼轴长度延长,MDA升高(P＜0.05)。实验后,ATR1组和ATR2组右眼屈光度、SOD高于左眼,眼轴长度短于左眼,MDA低于左眼(P＜0.05)。实验后,右眼屈光度和SOD ATR2组＞ATR1组＞对照组,眼轴长度和MDA ATR2组＜ATR1组＜对照组(P＜0.05)。阿托品可有效延缓巩膜病理进展。 结论2次/天低浓度阿托品滴眼可显著延缓LIM豚鼠屈光度、眼轴长度长,延缓巩膜病理进展,并抑制组织内氧化应激。 |
| 英文摘要: |
| AimTo investigate the effects of low-concentration of atropine (ATR) on refraction, axial length, and scleral oxidative stress in lens-induced myopia (LIM) guinea pigs. MethodsThirty LIM guinea pigs were randomly divided into control group (right eye treated with 0.3% sodium hyaluronate once daily), ATR1 group (right eye treated with ATR once daily), and ATR2 group (right eye treated with ATR twice daily). Refraction, axial length, scleral histopathology, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) content were measured. ResultsAfter the experiment, the left eyes of all groups showed decreased refraction and SOD activity, increased axial length, and elevated MDA levels (P＜0.05). The right eyes of ATR1 and ATR2 groups exhibited higher refraction and SOD activity, shorter axial length, and lower MDA levels compared to the left eyes (P＜0.05). The right eyes showed refraction and SOD activity, following an order of ATR2 group ＞ ATR1 group ＞ control group, while axial length and MDA levels followed an order of ATR2 group ＜ ATR1 group ＜ control group (P＜0.05). ATR delayed scleral pathological progression. ConclusionLow-concentration of atropine administered twice daily significantly delayed refraction and axial length progression, inhibited scleral pathology, and reduced oxidative stress in LIM guinea pigs. |
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