| 徐彩娜,卢莎莎,俱闪闪,池立珍,辛末丹,许墨菊,于奇.血清Furin、pNF-H水平与急性脑梗死患者病情、疾病转归的关系.[J].中南医学科学杂志.,2025,(1):170-173. |
| 血清Furin、pNF-H水平与急性脑梗死患者病情、疾病转归的关系 |
| The relationship between serum Furin and pNF-H levels and disease state and outcome in patients with acute cerebral infarction |
| 投稿时间：2024-07-10 修订日期：2024-12-06 |
| DOI：10.15972/j.cnki.43-1509/r.2025.01.042 |
| 中文关键词: 急性脑梗死 Furin pNF-H 病情 疾病转归 [ |
| 英文关键词:acute cerebral infarction Furin pNF-H state of the disease disease outcome |
| 基金项目:廊坊市科学技术研究与发展计划(2021013117) |
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| 中文摘要: |
| 目的探讨血清弗林蛋白酶(Furin)、磷酸化神经丝重亚单位(pNF-H)水平与急性脑梗死(ACI)患者病情、疾病转归的关系。 方法选取急性脑梗死患者102例,根据NIHSS评分分为轻度组(n＝35)、中度组(n＝38)及重度组(n＝29)；根据疾病转归分为好转组(n＝80)和恶化组(n＝22)。比较各组血清Furin、pNF-H水平。采用Pearson相关法分析Furin、pNF-H与NIHSS评分关系,采用ROC曲线评估Furin、pNF-H对ACI疾病转归的预测价值,采用多因素Logistic回归分析疾病转归的影响因素。 结果恶化组年龄、入院NIHSS评分分层的比例与好转组比较,差异有统计学意义(P＜0.05)。ACI患者血清Furin、pNF-H水平轻度组＜中度组＜重度组,好转组＜恶化组(P＜0.05)。ACI患者血清Furin、pNF-H与NIHSS评分均呈正相关(P＜0.001)。年龄、入院NIHSS评分＞15分、血清Furin、pNF-H是ACI患者疾病转归的危险因素(P＜0.05)。血清Furin、pNF-H对ACI患者疾病转归具有一定预测价值,且联合预测时效能最佳(P＜0.05)。 结论ACI患者血清Furin、pNF-H与病情严重程度呈正相关,Furin、pNF-H联合检测对疾病转归的预测效能最佳。 |
| 英文摘要: |
| AimTo investigate the relationship between the levels of serum Furin and phosphorylated neurofilament heavy subunit (pNF-H) and the disease state and outcome of acute cerebral infarction (ACI). Methods102 patients with ACI were selected and divided into mild group (n＝35), moderate group (n＝38) and severe group (n＝29) according to NIHSS score. According to the disease outcome, the patients were divided into improvement group (n＝80) and deterioration group (n＝22). The levels of serum Furin and pNF-H were compared among all groups. Pearson correlation was used to analyze the relationship between Furin, pNF-H levels and NIHSS scores, ROC curve was used to evaluate the predictive value of Furin and pNF-H on the disease outcome of ACI, and multi-factor Logistic regression was used to analyze the influencing factors of disease outcome. ResultsThere were significant differences in age and stratified NIHSS score between the worsening group and the improving group (P＜0.05). Serum Furin and pNF-H levels in ACI patients were in an order of mild group ＜ moderate group ＜ severe group, and improved group ＜ deteriorating group (P＜0.05). Serum Furin, pNF-H were positively correlated with NIHSS scores in ACI patients (P＜0.001). Age, admission NIHSS score＞15 score, serum Furin and pNF-H were risk factors for disease outcome in ACI patients (P＜0.05). Serum Furin and pNF-H had a certain predictive value for the disease outcome of ACI patients, and the combined prediction was the best (P＜0.05). ConclusionSerum Furin and pNF-H were positively correlated with the severity of ACI patients, and Furin and pNF-H combined detection was the best predictor of disease outcome. |
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