| 张立杰,王晓玲,宋巧凤,贾洪娟,张振飞,周文华.冠心病患者PCI术后不同时间血清miR-93-5p、IL-25水平变化及其与冠状动脉ISR的关系.[J].中南医学科学杂志.,2025,(1):110-113. |
| 冠心病患者PCI术后不同时间血清miR-93-5p、IL-25水平变化及其与冠状动脉ISR的关系 |
| Relationship between serum miR-93-5p and IL-25 levels and coronary artery ISR in patients with coronary heart disease at different time after PCI |
| 投稿时间：2023-09-20 修订日期：2024-02-25 |
| DOI：10.15972/j.cnki.43-1509/r.2025.01.027 |
| 中文关键词: miR-93-5p 白细胞介素-25 经皮冠状动脉介入治疗 支架内再狭窄 影响因素 [ |
| 英文关键词:miR-93-5p interleukin-25 percutaneous coronary intervention therapy narrowing within the stent influencing factors |
| 基金项目:河北省医学科学研究课题计划项目(20210316) |
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| 中文摘要: |
| 目的探讨冠心病患者经皮冠状动脉介入(PCI)术后不同时间血清微小核糖核酸(miR)-93-5p、血清白细胞介素(IL)-25水平变化及其与冠状动脉支架内再狭窄(ISR)的关系。 方法选取行PCI术的冠心病患者222例为研究对象,根据PCI术后复查冠状动脉造影结果将其分为ISR组30例和非ISR组192例,检测所有患者术前1天和术后24 h、7天、6个月的血清miR-93-5p、IL-25水平并进行比较。采用多因素Logistic回归分析法分析ISR发生的相关影响因素。 结果术后7天ISR组的IL-25水平高于非ISR组(P＜0.05)。ISR组术后24 h、7天IL-25水平较术前1天升高(P＜0.05)；非ISR组术后24 h IL-25水平较术前升高(P＜0.05)。术后7天ISR组的血清miR-93-5p水平低于非ISR组(P＜0.05)。ISR组术后24 h、7天血清miR-93-5p水平较术前1天降低(P＜0.05)；非ISR组术后24 h血清miR-93-5p水平较术前1天降低(P＜0.05)。术后24 h及术后7天的IL-25水平是ISR发生的危险因素,术后24 h及术后7天的miR-93-5p水平是ISR发生的保护因素(P＜0.05)。 结论血清miR-93-5p、IL-25水平可作为预测冠心病患者PCI术后ISR的参考指标。 |
| 英文摘要: |
| AimTo investigate the correlation between serum microRNA (miR-93-5p) and serum interleukin (IL)-25 and in-stent restenosis (ISR) in patients with coronary heart disease at different time after percutaneous coronary intervention (PCI). MethodsA total of 222 patients with coronary heart disease who underwent PCI were selected as the study objects, and were divided into ISR group (30 cases) and non-ISR group (192 cases) according to the coronary angiography reexamination results after PCI. Serum miR-93-5p and IL-25 levels of all patients were detected and compared 1 day before surgery and 24 hours, 7 days and 6 months after surgery. The multiple logistic regression analysis was used to analyze the relevant influencing factors that lead to ISR occurrence. ResultsThe level of IL-25 in the ISR group was significantly higher than that in the non-ISR group (P＜0.05). In the ISR group, IL-25 levels at 24 h and 7 d after surgery were significantly higher than those at 1 d before surgery (P＜0.05); In the non-ISR group, IL-25 levels were significantly higher 24 h after surgery than before (P＜0.05). Intergroup comparison showed that the serum miR-93-5p level of the ISR group was significantly lower than that of the non-ISR group at 7 days after surgery (P＜0.05). In the ISR group, the level of serum miR-93-5p at 24 h and 7 d after surgery was significantly lower than that at 1d before surgery (P＜0.05). The level of serum miR-93-5p in the non-ISR group was significantly lower than that on the first day before surgery only 24 hours after surgery (P＜0.05). The level of IL-25 24 hours and 7 days after surgery was a risk factor for ISR, and the level of miR-93-5p 24 hours and 7 days after surgery was a protective factor for ISR (P＜0.05). ConclusionSerum miR-93-5p and IL-25 levels can be used as reference indexes to predict ISR in patients with coronary heart disease after PCI. |
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