| 周文勇,王欣,孙月,闫斌.血清GPC-4、PIVKA-Ⅱ水平对急性胆源性胰腺炎患者疾病转归的预测价值.[J].中南医学科学杂志.,2025,(1):85-88. |
| 血清GPC-4、PIVKA-Ⅱ水平对急性胆源性胰腺炎患者疾病转归的预测价值 |
| Prognostic value of serum GPC-4 and PIVKA-Ⅱ levels on disease outcome in patients with acute biliary pancreatitis |
| 投稿时间：2023-10-17 修订日期：2024-11-25 |
| DOI：10.15972/j.cnki.43-1509/r.2025.01.020 |
| 中文关键词: GPC-4 PIVKA-Ⅱ 急性胆源性胰腺炎 疾病转归 [ |
| 英文关键词:GPC-4 PIVKA-Ⅱ Acute biliary pancreatitis Disease outcome |
| 基金项目:河北省医学科学研究课题项目(20211618) |
|
| 摘要点击次数: 0 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的研究血清磷脂酰肌醇蛋白聚糖-4(GPC-4)、异常凝血酶原即维生素K缺乏或拮抗剂Ⅱ诱导蛋白(PIVKA-Ⅱ)水平对急性胆源性胰腺炎患者疾病转归的预测价值。 方法选择急性胆源性胰腺炎患者113例为观察组,根据急性生理学与慢性健康评分系统Ⅱ(APACHEⅡ)分为轻度组(n＝69)和中重度组(n＝44),根据疾病转归分为恶化组(n＝32)和好转组(n＝81)；另选择同期体检健康者92例为对照组。比较各组血清GPC-4、PIVKA-Ⅱ水平。分析各指标的相关性、疾病转归的影响因素以及GPC-4、PIVKA-Ⅱ对疾病转归的预测价值。 结果观察组血清PCT、CRP、GPC-4、PIVKA-Ⅱ、APACHEⅡ评分均高于对照组,中重度组高于轻度组,恶化组高于好转组(P＜0.05)。Pearson相关分析显示,血清GPC-4、PIVKA-Ⅱ与APACHEⅡ评分均呈正相关(P＜0.001)。多因素Logistic回归分析显示,血清GPC-4、PIVKA-Ⅱ、APACHEⅡ评分是急性胆源性胰腺炎疾病转归的危险因素(P＜0.05)。ROC曲线分析显示,血清GPC-4、PIVKA-Ⅱ二者联合检测对急性胆源性胰腺炎疾病转归具有良好的预测价值(P＜0.05)。 结论急性胆源性胰腺炎患者血清GPC-4、PIVKA-Ⅱ水平对其疾病转归具有良好的预测价值。 |
| 英文摘要: |
| AimTo investigate the predictive value of serum levels of glypican-4 (GPC-4), abnormal prothrombin, i.e., protein induced by vitamin K deficiency or antagonist-Ⅱ(PIVKA-Ⅱ), on disease outcome in patients with acute biliary pancreatitis. Methods113 patients with acute biliary pancreatitis were selected as observation group, and were divided into mild group (n＝69) and moderate and severe group (n＝44) according to acute physiology and Chronic Health Score System Ⅱ (APACHEⅡ), or divided into worsening group (n＝32) and improvement group (n＝81) according to disease outcome. In addition, 92 healthy subjects were selected as control group. Serum levels of GPC-4 and PIVKA-Ⅱ were compared among all groups. The correlation of each index, the influencing factors of disease outcome and the predictive value of GPC-4 and PIVKA-Ⅱ for disease outcome were analyzed. ResultsSerum PCT, CRP, GPC-4, PIVKA-Ⅱ and APACHEⅡ scores in observation group were higher than those in control group, higher in moderate to severe group compared with mild group, and higher in worsening group compared with improvement group (P＜0.05). Pearson correlation analysis showed that serum GPC-4, PIVKA-Ⅱ and APACHEⅡ scores were positively correlated (P＜0.001). Multivariate Logistic regression analysis showed that serum GPC-4, PIVKA-Ⅱ and APACHEⅡ scores were risk factors for the outcome of acute biliary pancreatitis (P＜0.05). ROC curve analysis showed that the combined detection of serum GPC-4 and PIVKA-Ⅱ had a good predictive value for the outcome of acute biliary pancreatitis (P＜0.05). ConclusionSerum levels of GPC-4 and PIVKA-Ⅱ in patients with acute biliary pancreatitis have good predictive value for their disease outcomes. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|