| 王欢欢,赵荣,韩春霞,庞楠楠.造血干细胞移植术后长期认知功能障碍的影响因素及其与睡眠和复发恐惧的相关性.[J].中南医学科学杂志.,2025,(1):45-48. |
| 造血干细胞移植术后长期认知功能障碍的影响因素及其与睡眠和复发恐惧的相关性 |
| Influencing factors of long-term cognitive impairment after hematopoietic stem cell transplantation surgery and their correlation with sleep and fear of recurrence |
| 投稿时间：2023-09-22 修订日期：2024-05-18 |
| DOI：10.15972/j.cnki.43-1509/r.2025.01.010 |
| 中文关键词: 造血干细胞移植 认知功能障碍 睡眠质量 复发恐惧 影响因素 [ |
| 英文关键词:HSCT cognitive impairment sleep quality fear of recurrence influencing factors |
| 基金项目:国家自然科学基金项目(81960039) |
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| 中文摘要: |
| 目的分析造血干细胞移植(HSCT)术后患者长期认知功能障碍的影响因素及其与睡眠和复发恐惧的相关性。 方法观察418例HSCT术后患者长期认知功能障碍的发生情况。根据认知功能障碍严重程度分为轻度障碍组、中度障碍组和重度障碍组。采用癌症治疗功能评估-认知功能量表(FACT-Cog)、癌症治疗功能评诂-骨髓移植量表(FACT-BMT)、匹茨堡睡眠质量指数(PSQI)、恐惧疾病进展简化量表(FoP-Q-SF)评估各组认知功能、生活质量、睡眠质量和复发恐惧情况。Logistic回归分析HSCT术后长期认知功能障碍严重程度的影响因素。采用Spearman相关分析PSQI、FoP-Q-SF与FACT-Cog评分的相关性。 结果HSCT术后长期认知功能障碍发生92例(22.0%),其中轻度30例(32.6%),中度40例(43.5%),重度22例(23.9%)。随着认知功能障碍程度加重,FACT-BMT评分中各维度和总分逐渐降低(P＜0.05),PSQI、FoP-Q-SF评分逐渐升高(P＜0.05)。PSQI、FoP-Q-SF评分是HSCT术后长期认知功能障碍严重程度的影响因素。PSQI、FoP-Q-SF评分与FACT-Cog评分呈正相关(P＜0.05)。 结论HSCT术后长期认知功能障碍发生率高；PSQI、FoP-Q-SF评分是HSCT术后长期认知功能障碍严重程度的影响因素,且与HSCT 术后患者长期认知功能障碍发生呈正相关。 |
| 英文摘要: |
| AimTo analyze the influencing factors of long-term cognitive impairment in patients after hematopoietic stem cell transplantation (HSCT) and their correlation with sleep and fear of recurrence. MethodsThe occurrence of long-term cognitive impairment in 418 patients after HSCT surgery were monitored. The patients were divided into mild impairment group, moderate impairment group, and severe impairment group based on the severity of cognitive impairment. The cognitive function, quality of life, sleep quality, and fear of recurrence in each group were evaluated by using the functional assessment of cancer therapy-cognitive function (FACT-Cog), the functional assessment of cancer therapy-bone marrow transplant (FACT-BMT), Pittsburgh sleep quality index(PSQI), and the fear of progression questionnaire-short form (FoP-Q-SF). The influencing factors of long-term cognitive impairment severity after HSCT surgery were analyzed by using Logistic regression. The correlation between PSQI, FoP-Q-SF, and FACT-Cog scores were examined by using Spearman correlation analysis. Results92 cases (22.0%) experienced long-term cognitive impairment after HSCT surgery, of which 30 cases (32.6%) were mild, 40 cases (43.5%) were moderate, and 22 cases (23.9%) were severe. As cognitive impairment worsened, the dimensions and total score of FACT-BMT score were decreased gradually (P＜0.05), while the PSQI and FoP-Q-SF scores were increased (P＜0.05). PSQI and FoP-Q-SF scores were influencing factors for the severity of long-term cognitive impairment after HSCT surgery. PSQI score, FoP-Q-SF score, and FACT-Cog score were positively correlated (P＜0.05). ConclusionThe incidence of long-term cognitive impairment after HSCT surgery is high. PSQI, FoP-Q-SF score are influencing factors for the severity of long-term cognitive impairment after HSCT surgery, and are positively correlated with long-term cognitive impairment in HSCT patients. |
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